{
  "abstract": "Antiretroviral therapy (ART) interruptions are common among people who inject drugs (PWID) and contribute to viral rebound, disease progression, and onward transmission. Data-to-Care (D2C) strategies, which use routine health data to identify and re-engage people living with HIV who have fallen out of care, are widely used in high-income settings but rarely evaluated in low- and middle-income countries. We piloted a Ukrainian Data-to-Care (UD2C) intervention integrated into the national HIV Medical Information System among HIV-positive PWID recently out of care. Four specialized HIV clinics were randomized to UD2C or care as usual (CAU), with 40 participants enrolled per clinic (n = 160). UD2C combined an optimized data query to identify out-of-care patients with multidisciplinary, acuity-based case management. Recruitment, data extraction, and intervention delivery were feasible across all clinics. Because recruitment required clinic attendance, the pilot assessed UD2C’s post-linkage care component rather than its re-engagement function. The primary analysis accounted for clinic-level clustering using cluster-robust standard errors. Median ART coverage during follow-up was higher in UD2C than CAU (97% vs. 89%; adjusted rate ratio 1.15, 95% CI 0.87–1.51); this difference was significant in the model-based sensitivity analysis but not in the primary clustered analysis. Viral suppression was achieved or maintained more often in UD2C than CAU (58.8% vs. 28.8%; adjusted odds ratio 4.6, 95% CI 1.76–12.1). The UD2C model was feasible to implement and evaluate using a cluster-randomized design and showed promising improvements in longitudinal viral suppression. A fully powered definitive trial is warranted to confirm effectiveness and inform national scale-up. The trial is registered at www.clinicaltrials.gov as NCT05821413.",
  "abstract_shown": true,
  "affiliations": [
    "Ukrainian Institute on Public Health Policy, 10 Bohdana Khmelnytskoho Str., Office 60, 01054 Kyiv, Ukraine",
    "National University of Kyiv-Mohyla Academy, Kyiv, Ukraine",
    "Department of Health, Behavior & Society, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA",
    "Department of Public Health Education, University of North Carolina Greensboro, Greensboro, NC, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kostyantyn Dumchev",
      "orcid": "0000-0003-2862-4977"
    },
    {
      "affs": [
        2
      ],
      "name": "Brian Weir"
    },
    {
      "affs": [
        2
      ],
      "name": "Khushee Prasad"
    },
    {
      "affs": [
        2
      ],
      "name": "Shannon Fuller",
      "orcid": "0000-0001-6070-8172"
    },
    {
      "affs": [
        2
      ],
      "name": "Farren Rodrigues"
    },
    {
      "affs": [
        3
      ],
      "name": "Julia Burlaka",
      "orcid": "0000-0002-7053-8178"
    },
    {
      "affs": [
        0
      ],
      "name": "Olena Makarenko"
    },
    {
      "affs": [
        0
      ],
      "name": "Tetiana Kiriazova",
      "orcid": "0000-0002-8480-6591"
    },
    {
      "affs": [
        2
      ],
      "name": "Jill Owczarzak",
      "orcid": "0000-0003-2380-5533"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/brntacvvzxrmf.bib",
  "cited_by": 0,
  "doi": "10.1007/s10461-026-05224-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696523/",
  "id": "brntacvvzxrmf",
  "issns": [
    "1090-7165",
    "1573-3254"
  ],
  "landing_url": "https://doi.org/10.1007/s10461-026-05224-0",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2725|HIV/AIDS Research and Interventions"
    ]
  ],
  "openalex": "W7168414388",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s10461-026-05224-0.pdf",
  "pmcid": "PMC13696523",
  "pmid": "42455468",
  "published": "2026-07-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/brntacvvzxrmf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:52Z",
      "native_id": "PMC13696523",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s10461-026-05224-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|HIV/AIDS Research and Interventions",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Feasibility and Preliminary Effectiveness of a Data-to-Care Intervention for HIV-Positive People Who Inject Drugs in Ukraine: A Pilot Cluster-Randomized Trial",
  "title_text": "Feasibility and Preliminary Effectiveness of a Data-to-Care Intervention for HIV-Positive People Who Inject Drugs in Ukraine: A Pilot Cluster-Randomized Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:51Z",
  "url": "https://research.draconitic.com/paper/brntacvvzxrmf",
  "venue": "AIDS and behavior",
  "versions": []
}