{
  "abstract": "; however, the specific effects of distinct food groups on microbiome dynamics are unclear, particularly in circumstances of extreme perturbation. Here we evaluated the relationship between diet and intestinal microbiome dynamics by precisely tracking 9,419 meals consumed by 173 patients who were hospitalized for haematopoietic cell transplantation and analysing subsequent microbiome changes. Bayesian inference applied to data from 158 patients with paired longitudinal microbiome samples revealed that the intake of sweets and sugars during antibiotic exposure predicted exacerbated microbial dysbiosis, manifesting as lowered α-diversity and greater expansion of the pathobiont Enterococcus. Experiments in mice also showed that sucrose supplementation increased and prolonged antibiotic-induced Enterococcus expansion. These data suggest that avoiding a diet rich in simple sugars during antibiotic treatment may mitigate microbiota disruption. Further studies in independent cohorts will offer opportunities to generalize these findings and evaluate microbiota-sparing interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA",
    "Department of Microbiology, NYU Langone Health Grossman School of Medicine, New York, NY, USA",
    "Institute for Systems Genetics, NYU Langone Health Grossman School of Medicine, New York, NY, USA",
    "Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, USA",
    "Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA",
    "Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Human Oncology & Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA",
    "Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA",
    "Haematology Unit, Department of Cellular Therapy, Hematology and Laboratory Medicine, Azienda Ospedaliero-Universitaria Senese, Siena, Italy",
    "Food and Nutrition Services, Memorial Sloan Kettering Cancer Center, New York, NY, USA",
    "Department of Biomedical Engineering, NYU Tandon School of Engineering, New York, NY, USA",
    "Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA",
    "Riddet Institute, Massey University, Palmerston North, New Zealand",
    "Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA",
    "Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA",
    "Division of Medicine, University of Washington, Seattle, WA, USA",
    "Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA",
    "Weill Cornell Medical College, New York, NY, USA",
    "City of Hope, Duarte, CA, USA. mvandenbrink@coh.org",
    "Department of Microbiology, NYU Langone Health Grossman School of Medicine, New York, NY, USA. jonas.schluter@nyulangone.org",
    "Institute for Systems Genetics, NYU Langone Health Grossman School of Medicine, New York, NY, USA. jonas.schluter@nyulangone.org",
    "Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA. jonas.schluter@nyulangone.org",
    "Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. peledj@mskcc.org",
    "Weill Cornell Medical College, New York, NY, USA. peledj@mskcc.org"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 44,
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      "name": "Oriana Miltiadous",
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      "name": "Corrado Zuanelli Brambilla",
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      "name": "Luigi A. Amoretti",
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      "name": "Caichen Duan",
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      "name": "Chenzhen Zhang",
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      "name": "Alexis Sullivan",
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      "name": "John B. Slingerland",
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      "name": "Paul A. Giardina",
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      "name": "Antonio L. C. Gomes",
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      "name": "Abigail J. Johnson",
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      "name": "Dan Knights",
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      "name": "Jonas Schlüter",
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  "bibtex": "https://research.draconitic.com/paper/brrjqw6fjvkkd.bib",
  "cited_by": 8,
  "doi": "10.1038/s41586-026-11077-3",
  "fulltext_url": null,
  "id": "brrjqw6fjvkkd",
  "issns": [
    "0028-0836",
    "1476-4687"
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  "landing_url": "https://doi.org/10.1038/s41586-026-11077-3",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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  "native_subjects": [
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      "1312|Gut microbiota and health"
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  "pdf_url": "https://www.nature.com/articles/s41586-026-11077-3.pdf",
  "pmcid": "PMC11507691",
  "pmid": "39463943",
  "published": "2026-09-30",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/brrjqw6fjvkkd.ris",
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
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  "title": "Sugar-rich foods exacerbate antibiotic-induced microbiome disruption",
  "title_text": "Sugar-rich foods exacerbate antibiotic-induced microbiome disruption",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T13:21:07Z",
  "url": "https://research.draconitic.com/paper/brrjqw6fjvkkd",
  "venue": "Nature",
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