{
  "abstract": "Alzheimer’s disease (AD) is the most common neurodegenerative disorder, yet effective disease-modifying therapies remain elusive. Here, we apply a semantic logic framework of Gene Ontology-based protein function prediction to identify ferroptosis-inhibitory proteins with potential neuroprotective activity. Guided by these predictions, we engineer selenium-modified apolipoprotein A1 supramolecular nanoparticles (Se-NDs) that intrinsically display glutathione peroxidase 4 (GPX4)-like catalytic activity and exhibit high brain penetrance. Se-ND suppresses lipid peroxidation, restores redox balance, and blocks ferroptotic neuronal death, thereby promoting mitochondrial repair and synaptic integrity and reversing structural and functional deficits underlying cognitive decline. Moreover, Se-ND synergizes with anti-inflammatory interventions and other AD-associated pathways. Our findings identify ferroptosis inhibition as a critical disease-modifying mechanism and establish Se-ND as a promising therapeutic avenue for Alzheimer’s disease.",
  "abstract_shown": true,
  "affiliations": [
    "School of Life Science and Technology, Northwestern Polytechnical University, Youyi West Road 127, Xi’an, Shaanxi 710072, China",
    "School of Life Science and Technology, Northwestern Polytechnical University, Youyi West Road 127, Xi’an, Shaanxi 710072, China; Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518055, China",
    "Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518055, China",
    "School of Computer Science, Northwestern Polytechnical University, Youyi West Road 127, Xi’an, Shaanxi 710072, China",
    "Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China",
    "School of Computer Science, Northwestern Polytechnical University, Youyi West Road 127, Xi’an, Shaanxi 710072, China; Corresponding author",
    "Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China; Corresponding author",
    "Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518055, China; Corresponding author",
    "School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China; Corresponding author"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xin Shen"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiantao Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Feiyuan Peng"
    },
    {
      "affs": [
        3
      ],
      "name": "Haile Zhao"
    },
    {
      "affs": [
        4
      ],
      "name": "Chunrui Qiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Shaohua Shen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yujie Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Shafi Ullah"
    },
    {
      "affs": [
        0
      ],
      "name": "Airong Qian"
    },
    {
      "affs": [
        5
      ],
      "name": "Xiaoqi Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Xuequn Shang"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiazuan Ni"
    },
    {
      "affs": [
        6
      ],
      "name": "Junqiu Liu"
    },
    {
      "affs": [
        7
      ],
      "name": "Xiubo Du"
    },
    {
      "affs": [
        8
      ],
      "name": "Yan Ge"
    },
    {
      "affs": [
        8
      ],
      "name": "Zhenhui Qi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bs3eqq1f2ykb0.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrp.2026.103614",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2666386426005205",
  "id": "bs3eqq1f2ykb0",
  "issns": [
    "2666-3864"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrp.2026.103614",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QC1-999"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7223270573",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/bs3eqq1f2ykb0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:59Z",
      "native_id": "e3e746975a43472194801012f1c95ff5",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.xcrp.2026.103614"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Selenium-engineered self-assembling protein nanoparticles rescue synaptic integrity and cognition via ferroptosis inhibition in Alzheimer’s mice",
  "title_text": "Selenium-engineered self-assembling protein nanoparticles rescue synaptic integrity and cognition via ferroptosis inhibition in Alzheimer’s mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:59Z",
  "url": "https://research.draconitic.com/paper/bs3eqq1f2ykb0",
  "venue": "Cell Reports Physical Science",
  "versions": []
}