{
  "abstract": "Temperature-responsive hydrogels provide hydrated matrices for regulating protein release near physiological temperature. Building on a previously developed p(ASF-AGE-NIPAAm) hydrogel platform, this study evaluated five formulations with ASF-AGE feed contents of 10.0-57.1 wt% as protein delivery carriers. The hydrogels exhibited lower critical solution temperatures (LCSTs) of 31.8-33.0 °C and reversible swelling-deswelling transitions during cyclic temperature switching between 20 and 40 °C. Increasing the ASF-AGE content decreased the equilibrium swelling ratio from 17.3 to 10.6 g/g, while the bovine serum albumin (BSA) encapsulation efficiency varied between 73.5% and 76.8% and the drug loading capacity decreased from 452.6 to 380.2 mg/g. BSA release was evaluated in phosphate-buffered saline (PBS, pH 7.4) and depended on both temperature and formulation: the apparent cumulative release at the end of the observation period ranged from 37.6% to 54.1% at 20 °C and from 38.4% to 61.2% at 37 °C. Release was higher at 37 °C, coinciding with thermally induced network contraction, and ASF-rich formulations generally released less BSA. These Results define a composition-property-release relationship for p(ASF-AGE-NIPAAm) hydrogels and show that the ASF content can be adjusted to balance protein loading against temperature-responsive release.",
  "abstract_shown": true,
  "affiliations": [
    "Liaoning Provincial Key Laboratory of Functional Textile Materials, Liaodong University, Dandong 118001, China.",
    "School of Textiles and Apparel, Liaodong University, Dandong 118001, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Boxiang Wang",
      "orcid": "0000-0002-3251-0887"
    },
    {
      "affs": [
        1
      ],
      "name": "Hangdan Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Hong Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jinyang Xie"
    },
    {
      "affs": [
        1
      ],
      "name": "Huihui Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bsn48nx573rgd.bib",
  "cited_by": 0,
  "doi": "10.3390/gels12100888",
  "fulltext_url": "https://europepmc.org/articles/PMC13704761",
  "id": "bsn48nx573rgd",
  "issns": [
    "2310-2861"
  ],
  "landing_url": "https://europepmc.org/article/MED/42929921",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1313|Hydrogels: synthesis, properties, applications"
    ]
  ],
  "openalex": "W7215083740",
  "pdf_url": "https://europepmc.org/articles/PMC13704761?pdf=render",
  "pmcid": "PMC13704761",
  "pmid": "42929921",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bsn48nx573rgd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929921",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929921"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Hydrogels: synthesis, properties, applications",
      "subfield": "general"
    }
  ],
  "title": "Temperature-Responsive Antheraea pernyi Silk Fibroin/Poly(N-isopropylacrylamide) Hydrogels for Controlled Protein Drug Delivery.",
  "title_text": "Temperature-Responsive Antheraea pernyi Silk Fibroin/Poly(N-isopropylacrylamide) Hydrogels for Controlled Protein Drug Delivery.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/bsn48nx573rgd",
  "venue": "Gels (Basel, Switzerland)",
  "versions": []
}