{
  "abstract": "Background: Paravalvular leak involving a prosthetic mitral valve (M-PVL) is a rare but serious complication after mitral valve replacement (MVR). This study evaluated contemporary outcomes after surgical correction of M-PVL and investigated factors associated with its recurrence.\n\nMethods: This retrospective study included 199 patients who underwent first-time surgical correction of M-PVL between 2002 and 2023 (mean age, 64.5±9.6 years; 55.8% female). Early and long-term outcomes, including all-cause mortality and recurrence, were analyzed using Cox proportional hazards and cause-specific hazards models. The median follow-up duration was 55.9 months (interquartile range, 30.3–96.4 months).\n\nResults: Seventy-two percent of the patients had undergone at least 2 previous open-heart operations. The most common concomitant procedures were tricuspid valve surgery (n=78; 39.2%) and aortic valve surgery (n=48; 24.1%). Leak site repair was performed in 81 patients (40.7%), and redo MVR was performed in 118 patients (59.3%). The overall operative mortality rate was 6.0% (n=12) and decreased over time from 12.5% to 2.5%. The 5- and 10-year all-cause mortality rates were 20.7% and 38.4%, respectively. Cox proportional hazards analysis identified several preoperative and operative factors, including the era of operation, that were associated with all-cause mortality. The cumulative incidence of recurrent M-PVL was 10.0% at 5 years and 36.2% at 10 years. Cause-specific hazards analysis identified no factors significantly associated with recurrent M-PVL. Outcomes did not differ significantly between leak site repair and redo MVR.\n\nConclusion: Early outcomes after surgical correction of M-PVL improved over the study period. However, recurrence remained common regardless of operative technique.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine Seoul Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Han Cho",
      "orcid": "0009-0006-5298-2108"
    },
    {
      "affs": [
        0
      ],
      "name": "Jae Woong Choi",
      "orcid": "0000-0002-0921-756X"
    },
    {
      "affs": [
        0
      ],
      "name": "Kyung Hwan Kim",
      "orcid": "0000-0002-2718-8758"
    },
    {
      "affs": [
        0
      ],
      "name": "Ho Young Hwang",
      "orcid": "0000-0002-8935-8118"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bss0fxfzh2k26.bib",
  "cited_by": 1,
  "doi": "10.5090/jcs.26.061",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13747771/",
  "id": "bss0fxfzh2k26",
  "issns": [
    "2765-1606",
    "2765-1614"
  ],
  "landing_url": "https://doi.org/10.5090/jcs.26.061",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "heading",
      "Valve"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7211894408",
  "pdf_url": "https://www.jchestsurg.org/journal/download_pdf.php?doi=10.5090/jcs.26.061",
  "pmcid": "PMC13747771",
  "pmid": "42706223",
  "published": "2026-11-05",
  "publisher": "Korean Society for Thoracic and Cardiovascular Surgery",
  "ris": "https://research.draconitic.com/paper/bss0fxfzh2k26.ris",
  "sources": [
    {
      "first_seen": "2026-11-13T12:25:13Z",
      "native_id": "PMC13747771",
      "source": "pmc",
      "url": "https://doi.org/10.5090/jcs.26.061"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Surgical Correction of Prosthetic Mitral Valve Paravalvular Leak: Analysis of Long-Term Outcomes",
  "title_text": "Surgical Correction of Prosthetic Mitral Valve Paravalvular Leak: Analysis of Long-Term Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-14T12:20:52Z",
  "url": "https://research.draconitic.com/paper/bss0fxfzh2k26",
  "venue": "Journal of Chest Surgery",
  "versions": []
}