{
  "abstract": "Immunogenic cell death (ICD) bridged local therapy and systemic immune activation by releasing damage-associated molecular patterns (DAMPs) that provoked antitumor responses. Pyroptosis, a pro-inflammatory cell death mode, induced local tumor demise and released cytokines that facilitated immune activation. In this study, we constructed a multifunctional cascade nanosystem CaO2/Cu-ZIF8/GOX (CaO2/CZ/GOX) that triggered mitochondrial oxidative stress through glucose consumption and ion homeostasis disturbance and cuproptosis, thereby amplifying tumor pyroptosis. The nanosystem utilized acid-responsive Cu-ZIF8 (CZ) as a carrier to load CaO2 and glucose oxidase (GOX). In the acidic tumor microenvironment (TME), CaO2 initiated cascaded H2O2 generation, while GOX concurrently consumed glucose and catalytically generated H2O2, synergistically exacerbating ion homeostasis disruption and mitochondrial oxidative stress. Meanwhile, Cu2+ released from Cu-ZIF8 participated in Fenton-like reactions to generate hydroxyl radicals (·OH), and accumulated Cu2+ further triggered FDX1-mediated cuproptosis. Collectively, these events resulted in reactive oxygen species (ROS) accumulation, ion homeostasis disruption, and mitochondrial damage, ultimately activating tumor cell pyroptosis and cuproptosis. In vitro and in vivo assays confirmed that CaO2/CZ/GOX NPs efficiently consumed glucose, selectively accumulated in tumor, and exhibited favorable biocompatibility. Moreover, they significantly inhibited Hepa1-6 tumor cell proliferation, effectively suppressed tumor recurrence and activated antitumor immunity. Overall, this nanosystem integrated a cascade of metabolic intervention, oxidative damage, cuproptosis, pyroptosis, and immune activation, offering a new strategy for tumor metabolic regulation and immune microenvironment remodeling.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China",
    "Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, China",
    "State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, Jilin, 130012, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chunhui Dong"
    },
    {
      "affs": [
        0
      ],
      "name": "Lingyu Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Heng Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuqiang Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Qimeihui Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Dengke Teng"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhixia Sun"
    },
    {
      "affs": [
        2
      ],
      "name": "Bolun Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Hongyu Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Peng Dong"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiarui Du"
    },
    {
      "affs": [
        0
      ],
      "name": "Guoqing Sui"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bsvsjt52z2vj9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103772",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738022/",
  "id": "bsvsjt52z2vj9",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://doi.org/10.1016/j.mtbio.2026.103772",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full Length Article"
    ],
    [
      "openalex",
      "2204|Nanoplatforms for cancer theranostics"
    ]
  ],
  "openalex": "W7223691266",
  "pdf_url": null,
  "pmcid": "PMC13738022",
  "pmid": "42991586",
  "published": "2026-10-26",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/bsvsjt52z2vj9.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:05Z",
      "native_id": "PMC13738022",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.mtbio.2026.103772"
    }
  ],
  "subjects": [],
  "title": "Multifunctional cascade nanosystem consumes glucose to trigger enhanced pyroptosis and cuproptosis for tumor immunotherapy",
  "title_text": "Multifunctional cascade nanosystem consumes glucose to trigger enhanced pyroptosis and cuproptosis for tumor immunotherapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:05Z",
  "url": "https://research.draconitic.com/paper/bsvsjt52z2vj9",
  "venue": "Materials Today Bio",
  "versions": []
}