{
  "abstract": "Visible light photocatalysis, which exploits the reactivity of molecules at their excited state, has triggered a paradigm shift in organic synthesis by enabling some very unique chemical transformations. Yet, achieving precise control of the enantioselectivity in such processes remains a major challenge. A promising strategy involves linking a synthetic transition metal photocatalyst within the chiral architecture of a biomolecule to create a highly selective artificial metallo-photoenzyme. However, such an artificial metalloenzyme that integrates the merits of biocatalysis and photocatalysis to promote abiological reactions with high enantioselectivity is still unknown. Here, we report an artificial metallo-photoDNAzyme resulting from the covalent anchoring of a visible light-absorbing iridium-based photocatalyst within a double-stranded (ds)DNA helix, exhibiting efficient triplet-triplet energy transfer and high levels of enantioselectivity in [2 + 2] intramolecular cycloadditions.",
  "abstract_shown": true,
  "affiliations": [
    "Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, Montpellier, France",
    "Université de Montpellier",
    "LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France",
    "Université de Toulouse",
    "University of Trento",
    "Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy",
    "Queen Mary University of London",
    "Department of Chemistry, Queen Mary University of London, London, UK",
    "Institut de Chimie de Nice",
    "Institut de Chimie de Nice UMR 7272, Université Côte d'Azur, CNRS, Nice, France",
    "LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France. yves.canac@lcc-toulouse.fr",
    "LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France. olivier.basle@lcc-toulouse.fr",
    "Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, Montpellier, France. michael.smietana@umontpellier.fr"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Zachary Pastorel",
      "orcid": "0009-0006-4975-6185"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Juliette Zanzi"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Mathieu Noël",
      "orcid": "0009-0002-3804-0705"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Alessio Bartocci",
      "orcid": "0000-0001-9413-0663"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Stellios Arseniyadis",
      "orcid": "0000-0001-6831-2631"
    },
    {
      "affs": [
        9,
        3
      ],
      "name": "Elise E. Dumont",
      "orcid": "0000-0002-2359-111X"
    },
    {
      "affs": [
        10,
        3
      ],
      "name": "Yves Canac",
      "orcid": "0000-0002-3747-554X"
    },
    {
      "affs": [
        11,
        1
      ],
      "name": "Olivier Baslé",
      "orcid": "0000-0002-4551-473X"
    },
    {
      "affs": [
        12
      ],
      "name": "Michaël Smietana",
      "orcid": "0000-0001-8132-7221"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bsxhhqf9fvy4f.bib",
  "cited_by": 7,
  "doi": "10.1038/s41467-026-72881-z",
  "fulltext_url": null,
  "id": "bsxhhqf9fvy4f",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-72881-z",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W4411066630",
  "pdf_url": "https://www.nature.com/articles/s41467-026-72881-z_reference.pdf",
  "pmcid": "PMC13409001",
  "pmid": "42129180",
  "published": "2026-05-13",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/bsxhhqf9fvy4f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:44Z",
      "native_id": "W4411066630",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41467-026-72881-z"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "A metal-DNA biohybrid as enantioselective artificial photoDNAzyme",
  "title_text": "A metal-DNA biohybrid as enantioselective artificial photoDNAzyme",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:39Z",
  "url": "https://research.draconitic.com/paper/bsxhhqf9fvy4f",
  "venue": "Nature Communications",
  "versions": []
}