{
  "abstract": "The dynamic choreography of biomolecular interactions underpins the processes of life, but its direct observation remains challenging. Here we introduce continuous mass photometry, enabling hour-long, mass-resolved observation of individual biomolecules tethered to supported lipid bilayers, their complexes and interactions, with up to sub-kilodalton mass precision and millisecond temporal resolution. Our approach represents a quantitative time-resolved single-molecule measurement modality for studying complex biomolecular mechanisms in action.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, UK",
    "Biochemistry Building, Kavli Institute for Nanoscience Discovery, Oxford, UK",
    "Department of Biochemistry, University of Oxford, Oxford, UK",
    "MRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK",
    "CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, University of Oxford, Oxford, UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Dan Loewenthal",
      "orcid": "0000-0001-5303-1714"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Roi Asor"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Stephen Thorpe"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jack S. Peters"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Konstantin C. Zouboulis",
      "orcid": "0000-0003-3246-219X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Merve Kaplan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jan Christoph Thiele",
      "orcid": "0000-0002-6638-6298"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jack Bardzil",
      "orcid": "0009-0005-1547-5644"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Seham Helmi",
      "orcid": "0000-0001-5564-7459"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Sean A. Burnap"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Tiong Kit Tan",
      "orcid": "0000-0001-8746-8308"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Weston B. Struwe"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Justin L. P. Benesch",
      "orcid": "0000-0002-1507-3742"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Philipp Kukura",
      "orcid": "0000-0003-0136-7704"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bt705vsnx5ec2.bib",
  "cited_by": 2,
  "doi": "10.1038/s41592-026-03252-1",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736520/",
  "id": "bt705vsnx5ec2",
  "issns": [
    "1548-7091",
    "1548-7105"
  ],
  "landing_url": "https://doi.org/10.1038/s41592-026-03252-1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Communication"
    ],
    [
      "openalex",
      "1304|Advanced Fluorescence Microscopy Techniques"
    ]
  ],
  "openalex": "W7127443778",
  "pdf_url": "https://www.nature.com/articles/s41592-026-03252-1.pdf",
  "pmcid": "PMC13736520",
  "pmid": "42934324",
  "published": "2026-10-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bt705vsnx5ec2.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:56Z",
      "native_id": "PMC13736520",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41592-026-03252-1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1304|Advanced Fluorescence Microscopy Techniques",
      "subfield": "biophysics"
    }
  ],
  "title": "Continuous mass photometry by single-molecule trapping",
  "title_text": "Continuous mass photometry by single-molecule trapping",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:56Z",
  "url": "https://research.draconitic.com/paper/bt705vsnx5ec2",
  "venue": "Nature Methods",
  "versions": []
}