{
  "abstract": "Shigellosis is the second leading cause of diarrheal death in children under 5 years globally, yet no licensed vaccine exists, partly due to poor understanding of protective immunity in young children, especially in endemic settings. Here, we applied a functional antibody-profiling approach to define Shigella-specific antibody responses in young children versus older individuals with culture-confirmed shigellosis in Bangladesh. We found that higher baseline O-specific polysaccharide (OSP)-specific and protein-specific IgG and FcγR binding levels correlated with less severe disease regardless of age. We also found that over time, individuals under 5 years of age developed a less functional and durable response against OSP than older individuals. We demonstrate that OSP-specific IgG increased uptake of live Shigella by monocytes and macrophages in an Fc-dependent mechanism. Our findings suggest that young children develop limited OSP-specific functional antibody responses that fail to maximally involve innate immune cells. Innate cell clearance may be important in protecting against Shigella.",
  "abstract_shown": true,
  "affiliations": [
    "Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA",
    "The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel",
    "Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA",
    "Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA",
    "Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA",
    "International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh",
    "Department of Medicine, Harvard Medical School, Boston, MA, USA",
    "LBC, National Institutes of Health, NIDDK, Bethesda, MD, USA",
    "Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA",
    "Latham BioPharm Group, Cambridge, MA, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Biana Bernshtein"
    },
    {
      "affs": [
        0
      ],
      "name": "Julia A. Zhiteneva"
    },
    {
      "affs": [
        2
      ],
      "name": "Jeshina Janardhanan"
    },
    {
      "affs": [
        2
      ],
      "name": "Chanchal Wagh"
    },
    {
      "affs": [
        2
      ],
      "name": "Meagan Kelly"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Smriti Verma"
    },
    {
      "affs": [
        3
      ],
      "name": "Christina S. Faherty"
    },
    {
      "affs": [
        4
      ],
      "name": "Angel Nikolov"
    },
    {
      "affs": [
        0
      ],
      "name": "Wonyeong Jung"
    },
    {
      "affs": [
        5
      ],
      "name": "Salima Raiyan Basher"
    },
    {
      "affs": [
        5
      ],
      "name": "Mohammad Ashraful Amin"
    },
    {
      "affs": [
        5
      ],
      "name": "Shakil Mahamud"
    },
    {
      "affs": [
        5
      ],
      "name": "Nazmul Hasan Rajib"
    },
    {
      "affs": [
        5
      ],
      "name": "Fahima Chowdhury"
    },
    {
      "affs": [
        5
      ],
      "name": "Ashraful Islam Khan"
    },
    {
      "affs": [
        2,
        4,
        6
      ],
      "name": "Richelle C. Charles"
    },
    {
      "affs": [
        7
      ],
      "name": "Peng Xu"
    },
    {
      "affs": [
        7
      ],
      "name": "Pavol Kováč"
    },
    {
      "affs": [
        8
      ],
      "name": "Subhra Chakraborty"
    },
    {
      "affs": [
        9
      ],
      "name": "Robert W. Kaminski"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Galit Alter"
    },
    {
      "affs": [
        5
      ],
      "name": "Taufiqur R. Bhuiyan"
    },
    {
      "affs": [
        5
      ],
      "name": "Firdausi Qadri"
    },
    {
      "affs": [
        2,
        4,
        6
      ],
      "name": "Edward T. Ryan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bt813z3e1zwe5.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrm.2026.103076",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710543/",
  "id": "bt813z3e1zwe5",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103076",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "heading",
      "Article"
    ],
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      "openalex",
      "1310|Escherichia coli research studies"
    ]
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  "openalex": "W7214229934",
  "pdf_url": null,
  "pmcid": "PMC13710543",
  "pmid": "42785303",
  "published": "2026-09-24",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/bt813z3e1zwe5.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:29Z",
      "native_id": "PMC13710543",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103076"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1310|Escherichia coli research studies",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Functional O-specific polysaccharide-specific antibody responses in young children following Shigella infection in Bangladesh",
  "title_text": "Functional O-specific polysaccharide-specific antibody responses in young children following Shigella infection in Bangladesh",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:29Z",
  "url": "https://research.draconitic.com/paper/bt813z3e1zwe5",
  "venue": "Cell Reports Medicine",
  "versions": []
}