{
  "abstract": "Gut dysbiosis compromises cancer immunosurveillance by downregulating ileal mucosal addressin cell adhesion molecule 1 (MAdCAM-1), but the metabolic landscape associated with gut dysbiosis remains elusive. Here, we show that antibiotics (ABX) or ABX-associated Enterocloster species lead to the loss of secondary bile acids (BAs) including deoxycholic acid (DCA) and the accumulation of tauro-conjugated primary BAs (tauro-chenodeoxycholic acid [TCDCA] and tauro-β-muricholic acid [T-βMCA]) from the alternative pathway in the plasma of patients and mice. Fecal microbial transplantation (FMT), the ileum-specific farnesoid X receptor (FXR) agonist fexaramine, or glycodeoxycholic acid (GDCA) compensated dysbiosis-associated BA abnormalities and circumvent primary resistance to PD-1 blockade. GDCA curtailed ABX-induced MAdCAM-1 downregulation and T cell exhaustion in tumors. Subclinical cholestasis defined by elevation of γ-glutamyl transferase (γGT) correlated with increased TCDCA and decreased soluble MAdCAM-1 in plasma and predicted poor survival in multivariate analyses in six cohorts of patients who received immunotherapy. Hence, subclinical cholestasis accompanies gut dysbiosis, paving the way to immunoresistance.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 55,
  "authors": [
    {
      "name": "Anne-Laure Mallard de la Varende"
    },
    {
      "name": "Ai-Ling Tian"
    },
    {
      "name": "Simon Thomas"
    },
    {
      "name": "Imran Lahmar"
    },
    {
      "name": "Meriem Messaoudene"
    },
    {
      "name": "Sijing Li"
    },
    {
      "name": "Omar Motiño"
    },
    {
      "name": "Hortense Guillaume-Dit-Taunière"
    },
    {
      "name": "Valerio Iebba"
    },
    {
      "name": "Yoan Hurtado"
    },
    {
      "name": "Thao-Nguyen Pham"
    },
    {
      "name": "Cassandra Thélémaque"
    },
    {
      "name": "Miguel Araujo-Voces"
    },
    {
      "name": "Deborah Suissa"
    },
    {
      "name": "Pierre Ly"
    },
    {
      "name": "Ella Reich"
    },
    {
      "name": "Giacomo Vitali"
    },
    {
      "name": "Bryan Thierry Arlunno"
    },
    {
      "name": "Sylvere Durand"
    },
    {
      "name": "Fanny Aprahamian"
    },
    {
      "name": "Marion Leduc"
    },
    {
      "name": "Sabrina Forveille"
    },
    {
      "name": "Oliver Kepp"
    },
    {
      "name": "Carlos de la Calle-Fabregat"
    },
    {
      "name": "Angela Schippers"
    },
    {
      "name": "Norbert Wagner"
    },
    {
      "name": "Pierre-Edouard Fournier"
    },
    {
      "name": "Kenya Honda"
    },
    {
      "name": "Federica Marmorino"
    },
    {
      "name": "Chiara Cremolini"
    },
    {
      "name": "Saman Maleki Vareki"
    },
    {
      "name": "John G Lenehan"
    },
    {
      "name": "Aurélien Marabelle"
    },
    {
      "name": "François-Xavier Danlos"
    },
    {
      "name": "Margaux Deligne"
    },
    {
      "name": "Caroline Truntzer"
    },
    {
      "name": "François Ghiringhelli"
    },
    {
      "name": "Anne H Ree"
    },
    {
      "name": "Paula A Bousquet"
    },
    {
      "name": "Sebastian Meltzer"
    },
    {
      "name": "Florent Ginhoux"
    },
    {
      "name": "Deklan Rummel"
    },
    {
      "name": "Yousi Fu"
    },
    {
      "name": "Robert A Quinn"
    },
    {
      "name": "Carolina Alves Costa Silva"
    },
    {
      "name": "Roberto Iacovelli"
    },
    {
      "name": "Chiara Ciccarese"
    },
    {
      "name": "Serena Porcari"
    },
    {
      "name": "Arielle Elkrief"
    },
    {
      "name": "Bertrand Routy"
    },
    {
      "name": "Gianluca Ianiro"
    },
    {
      "name": "Lisa Derosa"
    },
    {
      "name": "Guido Kroemer"
    },
    {
      "name": "Marine Fidelle"
    },
    {
      "name": "Laurence Zitvogel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/btbkr8msak9ha.bib",
  "cited_by": 3,
  "doi": "10.1016/j.ccell.2026.06.022",
  "fulltext_url": null,
  "id": "btbkr8msak9ha",
  "issns": [
    "1535-6108"
  ],
  "landing_url": "https://hal.science/hal-05738805v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7171687684",
  "pdf_url": "https://hal.science/hal-05738805/document",
  "pmcid": null,
  "pmid": "42526445",
  "published": "2026-07-29",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/btbkr8msak9ha.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "hal-05738805",
      "source": "hal",
      "url": "https://hal.science/hal-05738805v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy",
  "title_text": "Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:29Z",
  "url": "https://research.draconitic.com/paper/btbkr8msak9ha",
  "venue": "Cancer Cell",
  "versions": []
}