{
  "abstract": "Background: Soluble urokinase plasminogen activator receptor (suPAR) reflects systemic immune activation. We examined associations between serum suPAR and pulmonary/internal-medicine admission in adults presenting to the emergency department (ED) with respiratory symptoms. Methods: This prospective single-centre exploratory pilot included 87 adults (54 pathway admissions; 33 ED discharges). Serum suPAR concentrations were determined using four-parameter logistic calibration of an eight-point ELISA standard curve, with correction for the fivefold serum dilution. Exploratory adjusted logistic regression and single-marker ROC analyses were performed. Results: Median serum suPAR was 3440.0 (2497.5–4535.0) pg/mL overall, 3955.0 (2979.0–5559.0) pg/mL among admitted patients and 2832.5 (2216.0–3317.5) pg/mL among discharged patients (p < 0.001). The apparent AUC for suPAR was 0.765 (95% bootstrap CI 0.663–0.856). After adjustment for age-category midpoint, sex, SpO2 and log-CRP, the odds ratio for admission per 1-SD increase in log-suPAR was 2.43 (95% CI 1.18–4.98; p = 0.015); the corresponding estimate for log-CRP was 1.69 (0.93–3.07; p = 0.084). Conclusions: Serum suPAR was associated with pathway-specific admission after adjustment for CRP and selected clinical covariates. These exploratory findings do not establish incremental clinical utility and require external validation.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Human Pathophysiology, Department of Nursing, University of Thessaly, Gaiopolis, 41500 Larissa, Greece",
    "Pulmonology Department, General Hospital of Corfu, 491 00 Corfu, Greece",
    "Laboratory of Respiratory Disorders, Department of Nursing, University of Thessaly, Gaiopolis, 41500 Larissa, Greece",
    "Department of Respiratory Medicine, University of Thessaly, Biopolis, 41110 Larissa, Greece",
    "Public Health and Adults Immunization Laboratory, Department of Nursing, University of Thessaly, Gaiopolis, 41500 Larissa, Greece"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Anna Karpouza",
      "orcid": "0009-0007-5947-6985"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Paraskevi Kirgou"
    },
    {
      "affs": [
        3
      ],
      "name": "Vasiliki Sachtaridou",
      "orcid": "0009-0007-2364-3630"
    },
    {
      "affs": [
        4
      ],
      "name": "Dimitrios Papagiannis"
    },
    {
      "affs": [
        4
      ],
      "name": "Erasmia Rouka",
      "orcid": "0000-0003-2885-4510"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Foteini Malli",
      "orcid": "0000-0002-7595-6715"
    },
    {
      "affs": [
        3
      ],
      "name": "Ioannis Pantazopoulos",
      "orcid": "0000-0002-8846-519X"
    },
    {
      "affs": [
        1
      ],
      "name": "Ilias Papanikolaou"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Ourania S. Kotsiou",
      "orcid": "0000-0001-5219-6971"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/btbvzz0pf6y01.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15228857",
  "fulltext_url": null,
  "id": "btbvzz0pf6y01",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/22/8857",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-12",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/btbvzz0pf6y01.ris",
  "sources": [
    {
      "first_seen": "2026-11-13T00:21:26Z",
      "native_id": "10.3390/jcm15228857",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/22/8857"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Serum suPAR Associations with Clinical and Laboratory Variables and Emergency Department Disposition in Adults with Respiratory Symptoms: A Prospective Observational Cohort Study",
  "title_text": "Serum suPAR Associations with Clinical and Laboratory Variables and Emergency Department Disposition in Adults with Respiratory Symptoms: A Prospective Observational Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:20:47Z",
  "url": "https://research.draconitic.com/paper/btbvzz0pf6y01",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}