{
  "abstract": "IgA nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide, and its diagnosis still relies on invasive kidney biopsy. To identify noninvasive biomarkers and therapeutic targets, we applied a multi-ancestry Mendelian randomization (MR) framework using proteome-wide association data from an Icelandic population, with validation in independent Fenland and United Kingdom cohorts, followed by transcriptomic, single-cell RNA sequencing (scRNA-seq), and cell-cell communication analyses. Nineteen candidate proteins were identified, and Bayesian colocalization supported a shared genomic region for eight, including AIF1. Transcriptomic analysis revealed downregulation of AIF1 in peripheral blood mononuclear cells from patients with IgAN, and scRNA-seq localized this depletion to dendritic cells (DCs), with partial restoration 150 days after tonsillectomy. Clinical phenotype MR showed inverse associations between AIF1 and hematuria and albuminuria, and enzyme-linked immunosorbent assay (ELISA) showed reduced circulating AIF1 in patients. AIF1 may protect against IgAN through DC-mediated antigen presentation, representing a candidate noninvasive biomarker and therapeutic target.",
  "abstract_shown": true,
  "affiliations": [
    "School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, China.",
    "Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.",
    "Guangdong Geriatric Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.",
    "Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.",
    "The First Clinical Medical School of Gannan Medical University, Ganzhou, Jiangxi Province, 341000, China.",
    "Department of Nephropathy, Dongguan Tungwah Hospital, Dongguan, Guangdong Province, 523015, China.",
    "Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xingyu Liu"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yiyang Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenjia Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Chaohong Nie"
    },
    {
      "affs": [
        4
      ],
      "name": "Fengxia Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Yufeng Liu"
    },
    {
      "affs": [
        5
      ],
      "name": "Xiaoyan Su"
    },
    {
      "affs": [
        6
      ],
      "name": "Shuangxin Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Quhuan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/btc523qygspxc.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jtauto.2026.100407",
  "fulltext_url": "https://europepmc.org/articles/PMC13678103",
  "id": "btc523qygspxc",
  "issns": [
    "2589-9090"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898749",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Renal Diseases and Glomerulopathies"
    ]
  ],
  "openalex": "W7220908925",
  "pdf_url": "https://europepmc.org/articles/PMC13678103?pdf=render",
  "pmcid": "PMC13678103",
  "pmid": "42898749",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/btc523qygspxc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898749",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898749"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Renal Diseases and Glomerulopathies",
      "subfield": "general"
    }
  ],
  "title": "Integrating multiple omics approaches to identify AIF1 as a protective factor in IgA nephropathy.",
  "title_text": "Integrating multiple omics approaches to identify AIF1 as a protective factor in IgA nephropathy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/btc523qygspxc",
  "venue": "Journal of translational autoimmunity",
  "versions": []
}