{
  "abstract": "B cell-derived immunoglobulin E (IgE) plays a crucial role in the development of allergic asthma. However, the intrinsic regulation of B cell function in this context is not fully understood. Here we investigated the role of Ssu72 phosphatase expressed in B cells during house dust mite (HDM)-induced asthma. Ssu72 expression was significantly increased in B cells stimulated with anti-CD40 and IL-4, as well as in B cells infiltrating the lungs of HDM-induced asthmatic mice. Notably, mice with B cell-specific deletion of Ssu72 exhibited considerably milder lung inflammation and lower serum levels of IgG1 and IgE compared to wild-type mice in HDM-induced asthma. In addition, the absence of Ssu72 in B cells resulted in a reduction in the number of IgG1- and IgE class-switched B cells and a decrease in soluble CD23 production, which correlated with lower expression of a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) and matrix metalloproteinase 9 (MMP9). Mechanistically, our findings suggest that Ssu72 deficiency may dysregulate the AMPK–mTORC1 balance through hyperphosphorylation of AMPKα. In adoptive transfer experiments, Ssu72-deficient B cells were less effective than wild-type B cells in promoting the effector phase of HDM-induced asthma in B cell-deficient hosts following HDM sensitization. Furthermore, B cell-specific deletion of Ssu72 led to the reduced production of IL-4 and IL-13 by CD4⁺ T cells and diminished MHC class II upregulation in lymph nodes and lung B cells during HDM-induced asthma. These findings identify B cell Ssu72 as a crucial regulator of B cell activation and function in allergic asthma.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea",
    "Department of Immunology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea",
    "Personalized Cancer Immunotherapy Research Center, Sungkyunkwan University, Suwon, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Seo-Young Koo"
    },
    {
      "affs": [
        0
      ],
      "name": "Naiyu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Min-Hee Kim",
      "orcid": "0000-0003-1433-5699"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Sujin Lee"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Tae Jin Kim",
      "orcid": "0000-0001-9802-0568"
    },
    {
      "affs": [
        0
      ],
      "name": "Chang-Woo Lee",
      "orcid": "0000-0002-0943-1646"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/btgy59y982k3x.bib",
  "cited_by": 0,
  "doi": "10.1038/s12276-026-01859-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737138/",
  "id": "btgy59y982k3x",
  "issns": [
    "1226-3613",
    "2092-6413"
  ],
  "landing_url": "https://doi.org/10.1038/s12276-026-01859-0",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2740|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7220450721",
  "pdf_url": "https://www.nature.com/articles/s12276-026-01859-0.pdf",
  "pmcid": "PMC13737138",
  "pmid": "42834111",
  "published": "2026-10-05",
  "publisher": "Korean Society for Biochemistry and Molecular Biology",
  "ris": "https://research.draconitic.com/paper/btgy59y982k3x.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:25Z",
      "native_id": "PMC13737138",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s12276-026-01859-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Asthma and respiratory diseases",
      "subfield": "general"
    }
  ],
  "title": "B cell-intrinsic Ssu72 phosphatase is a key regulator of allergic asthma",
  "title_text": "B cell-intrinsic Ssu72 phosphatase is a key regulator of allergic asthma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:25Z",
  "url": "https://research.draconitic.com/paper/btgy59y982k3x",
  "venue": "Experimental & Molecular Medicine",
  "versions": []
}