{
  "abstract": "Medin, a 50-residue fragment of lactadherin (MFG-E8), forms aortic medial amyloid, the most common localized amyloid in humans, and co-deposits with vascular amyloid-{beta} (A{beta}) in Alzheimer's disease. In the full-length medin fibril the N-terminal half forms the entire protofilament interface, yet the strongest predicted amyloidogenic determinants lie in the C-terminal region. Here we show that this region aggregates on its own. The isolated C-terminal aggregation-prone region (medin C-APR, medin 31-53) begins to aggregate with the same lag time as full-length medin and assembles into two coexisting polymorphs, determined here by cryo-EM at 2.71 and 2.91 [A]. Both are built from the same two-stranded {beta}-arch and a pseudo-21 protofilament pair closed by an aromatic-aliphatic zipper, and differ only in how many accessory chains the exposed hydrophobic face recruits. The medin C-terminus therefore carries an amyloid core of its own, unrelated to that of the full-length fibril: medin has more than one aggregation-prone region, and the structural contribution of each region depends on sequence and assembly context.",
  "abstract_shown": true,
  "affiliations": [
    "VIB & KU Leuven center for Neuroscience"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "B. Pradhan"
    },
    {
      "name": "F. Rousseau"
    },
    {
      "affs": [
        0
      ],
      "name": "J. Schymkowitz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/btt2bc1b5hkyt.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.29.762820",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762820v1.full",
  "id": "btt2bc1b5hkyt",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762820v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biochemistry"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762820v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/btt2bc1b5hkyt.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:21:07Z",
      "native_id": "10.64898/2026.10.29.762820",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762820v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biochemistry",
      "subfield": "general"
    }
  ],
  "title": "Two polymorphs of an independent amyloid core in medin's C-terminal region.",
  "title_text": "Two polymorphs of an independent amyloid core in medin's C-terminal region.",
  "type": "preprint",
  "updated_at": "2026-11-01T00:20:48Z",
  "url": "https://research.draconitic.com/paper/btt2bc1b5hkyt",
  "venue": "bioRxiv",
  "versions": []
}