{
  "abstract": "Purpose\n\nDiabetic polyneuropathy (DPN) is a debilitating complication of diabetes that affects motor nerves and may impair skeletal muscle health. This study investigated skeletal muscle proteomic alterations associated with DPN compared with type 2 diabetes without DPN (T2D) and healthy controls (CON).Experimental design\n\nAn exploratory proteomic profiling was performed in 15 participants divided into three groups based on clinical and neurophysiological diagnosis (DPN, n = 5; T2D, n = 5; CON, n = 5). Biopsies from the gastrocnemius lateralis muscle were analyzed using LC-MS/MS-based proteomics and pathway enrichment analyses.Results\n\nA total of 265 and 444 proteins were differentially expressed in DPN compared with T2D and CON, respectively (q < 0.05). Enrichment analyses revealed marked alterations in mitochondrial-related pathways, including cellular respiration, distinguishing DPN from both comparison groups. Differences between T2D and CON were present but less pronounced. DPN was characterized by downregulation of glycogen-regulating proteins (phosphorylase kinase G1 and A1) and upregulation of ferritin light chain (FTL), alpha actin 2, and myosin-binding protein H.Conclusions and clinical relevance\n\nDPN is associated with a distinct and progressive skeletal muscle proteomic phenotype, supporting mitochondrial dysfunction as a key feature and providing a basis for future mechanistic and therapeutic studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedicine, Aarhus University, Aarhus, Denmark.",
    "Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.",
    "Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.",
    "NMD Pharma A/S, Aarhus, Denmark.",
    "Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.",
    "Research Unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Frederik Forsberg Thybo",
      "orcid": "0009-0001-4877-3593"
    },
    {
      "affs": [
        2
      ],
      "name": "Karolina Snopek Khan"
    },
    {
      "affs": [
        3
      ],
      "name": "Jesper Emil Jakobsgaard",
      "orcid": "0000-0003-1818-9860"
    },
    {
      "affs": [
        2
      ],
      "name": "Henning Andersen"
    },
    {
      "affs": [
        4
      ],
      "name": "Kristian Vissing",
      "orcid": "0000-0001-5810-5241"
    },
    {
      "affs": [
        5
      ],
      "name": "Johan Palmfeldt",
      "orcid": "0000-0001-5585-639X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/btvgtzkr23kf5.bib",
  "cited_by": 0,
  "doi": "10.1002/prca.70060",
  "fulltext_url": "https://europepmc.org/articles/PMC13678273",
  "id": "btvgtzkr23kf5",
  "issns": [
    "1862-8346",
    "1862-8354"
  ],
  "landing_url": "https://europepmc.org/article/MED/42894376",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Muscle Physiology and Disorders"
    ]
  ],
  "openalex": "W7222951294",
  "pdf_url": "https://europepmc.org/articles/PMC13678273?pdf=render",
  "pmcid": "PMC13678273",
  "pmid": "42894376",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/btvgtzkr23kf5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42894376",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42894376"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Muscle Physiology and Disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype.",
  "title_text": "Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/btvgtzkr23kf5",
  "venue": "Proteomics. Clinical applications",
  "versions": []
}