{
  "abstract": "This cross-sectional exploratory study investigates the potential of metabolomics to differentiate between stable coronary artery disease (CAD) and acute myocardial infarction (AMI) through Nuclear Magnetic Resonance (NMR) spectroscopic analysis. The study identifies distinct metabolic profiles for each condition, revealing significant variations in metabolite levels, particularly lactic acid, which is a key metabolic product of anaerobic glycolysis, emerges as a prominent marker in AMI patients, reflecting acute ischemic stress and providing insight into adverse outcomes associated with high lactate levels. Another metabolite found in the present study was hypoxanthine, which is key biomarker for myocardial ischemia. These findings underscore the potential of metabolomics in combination with pathway analysis in distinguishing between CAD and AMI and highlight the metabolic dysregulation that occurs in these diseases. Our results suggest that these metabolites could serve as potential biomarkers, paving the way for personalized prognostic and diagnostic strategies. Further large-scale studies are necessary to validate these findings and incorporate them into clinical practice.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s12265-026-10866-5.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine and Cardiology, Medical School Theodor Fontane, University Hospital Ruppin-Brandenburg, 16816 Neuruppin, Germany",
    "Center for Translational Medicine, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany",
    "Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, 16816 Neuruppin, Germany",
    "Department of Gastroenterology, Diabetology and Hepatology, Center for Internal Medicine II, University Hospital Brandenburg an der Havel, Medical School Theodor Fontane, 14770 Brandenburg an der Havel, Germany",
    "3rd Department of Cardiology, Medical School, “Sotiria’’ Chest Disease Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece",
    "Medical Department II, Marien Hospital Herne, Ruhr-University of Bochum, 44625 Herne, Germany",
    "lifespin GmbH, 93053 Am BioPark 13, Regensburg, Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Nikolaos Pagonas",
      "orcid": "0000-0003-3226-8135"
    },
    {
      "affs": [
        3,
        1,
        2
      ],
      "name": "Werner Dammermann"
    },
    {
      "affs": [
        4
      ],
      "name": "Gerasimos Siasos"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Sawa Kostin"
    },
    {
      "affs": [
        5
      ],
      "name": "Benjamin Sasko"
    },
    {
      "affs": [
        2
      ],
      "name": "Philipp Sotiriou"
    },
    {
      "affs": [
        6
      ],
      "name": "Selina Strathmeyer"
    },
    {
      "affs": [
        6
      ],
      "name": "Steffen Heelemann"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/btvpavysvxfey.bib",
  "cited_by": 0,
  "doi": "10.1007/s12265-026-10866-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731718/",
  "id": "btvpavysvxfey",
  "issns": [
    "1937-5387",
    "1937-5395"
  ],
  "landing_url": "https://doi.org/10.1007/s12265-026-10866-5",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "1312|Metabolomics and Mass Spectrometry Studies"
    ]
  ],
  "openalex": "W7225144699",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s12265-026-10866-5.pdf",
  "pmcid": "PMC13731718",
  "pmid": "42975763",
  "published": "2026-11-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/btvpavysvxfey.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:51Z",
      "native_id": "PMC13731718",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s12265-026-10866-5"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Metabolomics and Mass Spectrometry Studies",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Metabolomic Analysis of Patients with Coronary Artery Disease and Acute Myocardial Infarction by Using Nuclear Magnetic Resonance Spectroscopy",
  "title_text": "Metabolomic Analysis of Patients with Coronary Artery Disease and Acute Myocardial Infarction by Using Nuclear Magnetic Resonance Spectroscopy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:51Z",
  "url": "https://research.draconitic.com/paper/btvpavysvxfey",
  "venue": "Journal of Cardiovascular Translational Research",
  "versions": []
}