{
  "abstract": "Many settings in sub-Saharan Africa use rapid antibody assays to detect human immunodeficiency virus (HIV) infection among blood donor candidates. This study aimed to evaluate the analytical performance of HIV serological tests used to screen blood donor candidates in Mozambique. Determine HIV 1/2 + Uni-Gold HIV (the routine HIV testing at blood banks in Mozambique), and two newer rapid tests (Determine HIV Early Detect and Meriscreen HIV1–2 Western Blot) were compared with an Enzyme-Linked Immunosorbent Assays (Merilisa HIV Gen 4 test + Uni-Gold HIV). Additionally, all serological tests were compared with the molecular cobas MPX test. The sensitivity and specificity of Determine HIV 1/2 + Uni-Gold HIV; Determine HIV Early Detect, and Meriscreen HIV1–2 Western Blot compared to the Merilisa HIV Gen 4 test + Uni-Gold were 85.5% and 99.6%; 88.7% and 99.5%; 90.0% and 99.6% respectively. The sensitivity and specificity of Determine HIV 1/2 + Uni-Gold HIV; Determine HIV Early Detect, Meriscreen HIV1–2 Western Blot, and Merilisa HIV Gen 4 test + Uni-Gold compared to the cobas MPX test were 64.0% and 99.1%; 68.6% and 99.1%; 70.8% and 99.0%; 66.0% and 99.4%, respectively. The probability of undetected positive results in the rapid tests and Merilisa HIV Gen 4 test ranged from 5.6 to 6.7 per 1,000 blood donors. The results of this study point to the need for the introduction of molecular testing for HIV in blood banks in developing countries to improve transfusion safety and contribute to controlling HIV as a public health problem.",
  "abstract_shown": true,
  "affiliations": [
    "Instituto Nacional de Saúde, Marracuene, Mozambique",
    "Clinton Health Access Initiative, Maputo city, Mozambique",
    "Universidade Eduardo Mondlane, Maputo city, Mozambique"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nédio Mabunda"
    },
    {
      "affs": [
        1
      ],
      "name": "Odete Matola"
    },
    {
      "affs": [
        2
      ],
      "name": "Júlia Sambo"
    },
    {
      "name": "Imelda Chelene"
    },
    {
      "name": "Abras Munguambe"
    },
    {
      "name": "Nuro Abílio"
    },
    {
      "name": "Adolfo Vubil"
    },
    {
      "name": "Osvaldo Loquiha"
    },
    {
      "name": "Ilesh Jani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bvke4s0mwhe3c.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pgph.0007398",
  "fulltext_url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0007398",
  "id": "bvke4s0mwhe3c",
  "issns": [
    "2767-3375"
  ],
  "landing_url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0007398",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1405|Blood donation and transfusion practices"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/RNA viruses/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Clinical laboratory sciences/Transfusion medicine/Blood transfusion"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/HIV diagnosis and management"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Virus testing"
    ],
    [
      "plos",
      "/Medicine and health sciences/Health care/Blood donors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Health care/Health care facilities/Blood banks"
    ],
    [
      "plos",
      "/Medicine and health sciences/Hematology/Transfusion medicine/Blood transfusion"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Serology"
    ],
    [
      "plos",
      "/Research and analysis methods/Immunologic techniques/Immunoassays/Enzyme-linked immunoassays"
    ]
  ],
  "openalex": "W7214997656",
  "pdf_url": "https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0007398&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/bvke4s0mwhe3c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:37Z",
      "native_id": "10.1371/journal.pgph.0007398",
      "source": "plos",
      "url": "https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0007398"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "High transmission risk of Human Immunodeficiency Virus in blood transfusions: A critical evaluation of blood bank serological tests in Mozambique",
  "title_text": "High transmission risk of Human Immunodeficiency Virus in blood transfusions: A critical evaluation of blood bank serological tests in Mozambique",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:37Z",
  "url": "https://research.draconitic.com/paper/bvke4s0mwhe3c",
  "venue": "PLOS Global Public Health",
  "versions": []
}