{
  "abstract": "Background Hyperoxaluria is associated with calcium oxalate (CaOx) stone disease and is assessed by quantitative urinary oxalate excretion. We aimed to identify routinely available clinical factors associated with concurrent study-defined hyperoxaluria among adults with CaOx stones. Methods This single-center retrospective cross-sectional study included 385 adults with infrared-spectroscopy-confirmed CaOx stones who underwent stone surgery and completed at least one valid preoperative 24-hour urine collection 3–10 days before surgery between January 1 and December 1, 2024. Study-defined hyperoxaluria was urinary oxalate excretion ≥ 40 mg/24 h. The primary exploratory model used forward likelihood-ratio selection after univariable screening; a sensitivity model simultaneously included age, sex, body mass index, and the four factors retained by the stepwise model. Results Hyperoxaluria was present in 132 of 385 patients (34.3%). In the primary stepwise model, hyperlipidemia (odds ratio [OR] 1.591, 95% confidence interval [CI] 1.031–2.457; P = 0.036), a positive urine nitrite test (OR 2.356, 95% CI 1.114–4.986; P = 0.025), diabetes mellitus (OR 1.811, 95% CI 1.055–3.109; P = 0.031), and at least two previous stone operations (OR 1.632, 95% CI 1.048–2.541; P = 0.030) were associated with hyperoxaluria. In the prespecified sensitivity model, all effect directions were unchanged, but hyperlipidemia was not statistically significant (OR 1.499, 95% CI 0.966–2.326; P = 0.071); the other three associations remained statistically significant. Conclusions In surgically treated adults with composition-confirmed CaOx stones, the stepwise model identified four concurrent correlates of study-defined hyperoxaluria, whereas sensitivity analysis indicated that the hyperlipidemia association was model-dependent. The associations with a positive urine nitrite test, diabetes mellitus, and at least two previous stone operations were more stable across models. These exploratory indicators may help prioritize confirmatory 24-hour urine testing where access is limited, but they cannot replace metabolic evaluation or establish causality.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, The First Affiliated Hospital of Guangzhou Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yingpan Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lili Ou"
    },
    {
      "affs": [
        0
      ],
      "name": "Fuyang Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiapeng Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Junhao Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongda Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bvs5hd0z8z7ad.bib",
  "cited_by": 0,
  "doi": "10.1186/s12894-026-02344-6",
  "fulltext_url": "https://doi.org/10.1186/s12894-026-02344-6",
  "id": "bvs5hd0z8z7ad",
  "issns": [
    "1471-2490"
  ],
  "landing_url": "https://doi.org/10.1186/s12894-026-02344-6",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC870-923"
    ],
    [
      "openalex",
      "2740|Kidney Stones and Urolithiasis Treatments"
    ]
  ],
  "openalex": "W7212187549",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/bvs5hd0z8z7ad.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:20Z",
      "native_id": "4677c24b191b423d9bea6e6bcfa1fd76",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12894-026-02344-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Kidney Stones and Urolithiasis Treatments",
      "subfield": "general"
    }
  ],
  "title": "Analysis of clinical factors for hyperoxaluria in patients with calcium oxalate stones: a single-center retrospective cross-sectional study",
  "title_text": "Analysis of clinical factors for hyperoxaluria in patients with calcium oxalate stones: a single-center retrospective cross-sectional study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:20Z",
  "url": "https://research.draconitic.com/paper/bvs5hd0z8z7ad",
  "venue": "BMC Urology",
  "versions": []
}