{
  "abstract": "Neurocognitive impairments (NCI) affect up to 50% of persons living with HIV (PLWH), even under anti-retroviral therapy. Evidence suggests that HIV-1 genotypes at least in part contribute to NCI, but most studies considered composite scores and did not examine specific neurocognitive domains. We considered neurocognitive domains assessed in the Neurocognitive Assessment in the Metabolic and Ageing Cohort, a sub study of the Swiss HIV Cohort Study (SHCS), and determined associations with HIV-1 residues, detected by full-length genome sequencing, previously linked to self-reported neurocognitive complaints (SRNC) in the SHCS, using linear regression. Additionally, we determined the heritability with Brownian motion- and mixed models based on viral pol phylogenies. In 192 out of 981 PLWH with full-length sequences, among the top residue variants identified, Env641E and Rev18I had been previously associated with SRNC. Respectively, of identified residue variants, point estimates correlated highly with previous SRNC-estimates from the SHCS for sensory skills (r = -0.71, P < 0.0001) and speed of processing (r = -0.71, P < 0.0001). Heritability estimates in 981 PLWH were significant for sensory skills [25.9%, 95% confidence interval (CI) 5.5-44.6%], motor skills (24.3%, CI 3.7-43.3%), and speed of processing (23.5%, CI 5.2-40.7%). Our findings support prior observations regarding SRNC-associated viral residues and confirm the relevance of the infecting HIV-1 strains for neurocognitive performances.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich 8091, Switzerland.",
    "Institute of Medical Virology, University of Zurich, Zurich 8057, Switzerland.",
    "Division of Infectious Diseases and Leenaards Memory Centre, Lausanne University Hospital, University of Lausanne, Lausanne 1011, Switzerland.",
    "Division of Infectious Diseases, Ente Ospedaliero Cantonale, Lugano 6500, Switzerland.",
    "Department of Biomedical Sciences, University of Geneva and University of Southern Switzerland, Lugano 6900, Switzerland.",
    "Center for Infectious Diseases, Klinik im Park, Zurich 8027, Switzerland.",
    "Clinical Virology, University Hospital Basel, Basel 4031, Switzerland.",
    "Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen 9007, Switzerland.",
    "Division of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, Lausanne 1011, Switzerland.",
    "Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland.",
    "Institute for Infectious Diseases and Multidisciplinary Center for Infectious Diseases, University of Bern, Bern 3012, Switzerland.",
    "Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University Basel, Basel 4031, Switzerland.",
    "Laboratory of Virology and Division of Infectious Diseases, Geneva University Hospital, University of Geneva, Geneva 1205, Switzerland.",
    "HIV/AIDS Unit, Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva 1205, Switzerland.",
    "Faculty of Medicine, University of Geneva, Geneva 1205, Switzerland.",
    "Division of Infectious Diseases, Lausanne University Hospital, University of Lausanne, Lausanne 1011, Switzerland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Marius Zeeb",
      "orcid": "0000-0001-6822-1473"
    },
    {
      "affs": [
        2
      ],
      "name": "Mélanie Bieler-Aeschlimann"
    },
    {
      "affs": [
        0
      ],
      "name": "Paul Frischknecht"
    },
    {
      "affs": [
        0
      ],
      "name": "Kathrin Neumann",
      "orcid": "0000-0001-5034-6999"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lisa Jörimann"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jasmin Tschumi",
      "orcid": "0009-0007-4163-6338"
    },
    {
      "affs": [
        1
      ],
      "name": "Michael Huber",
      "orcid": "0000-0002-0384-0000"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Katharina Kusejko"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Enos Bernasconi",
      "orcid": "0000-0002-9724-8373"
    },
    {
      "affs": [
        5
      ],
      "name": "Helen Kovari",
      "orcid": "0000-0003-4896-4231"
    },
    {
      "affs": [
        6
      ],
      "name": "Karoline Leuzinger"
    },
    {
      "affs": [
        7
      ],
      "name": "Julia Notter",
      "orcid": "0000-0003-4821-9995"
    },
    {
      "affs": [
        8
      ],
      "name": "Matthieu Perreau",
      "orcid": "0000-0003-2110-2244"
    },
    {
      "affs": [
        9
      ],
      "name": "Cornelia Staehelin",
      "orcid": "0000-0002-1733-7051"
    },
    {
      "affs": [
        10
      ],
      "name": "Alban Ramette"
    },
    {
      "affs": [
        11
      ],
      "name": "Marcel Stöckle",
      "orcid": "0000-0002-0088-5078"
    },
    {
      "affs": [
        12
      ],
      "name": "Sabine Yerly"
    },
    {
      "affs": [
        13,
        14
      ],
      "name": "Alexandra Calmy"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Karin J Metzner"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Huldrych F Günthard"
    },
    {
      "affs": [
        15
      ],
      "name": "Matthias Cavassini",
      "orcid": "0000-0003-0933-7833"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Roger D Kouyos"
    },
    {
      "name": "NAMACO Study Group and the Swiss HIV Cohort Study"
    },
    {
      "name": "NAMACO Study Group and the Swiss HIV Cohort Study"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bvx61eacbpmrh.bib",
  "cited_by": 0,
  "doi": "10.1093/braincomms/fcag371",
  "fulltext_url": "https://europepmc.org/articles/PMC13685630",
  "id": "bvx61eacbpmrh",
  "issns": [
    "2632-1297"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910189",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2406|HIV Research and Treatment"
    ]
  ],
  "openalex": "W7220649446",
  "pdf_url": "https://europepmc.org/articles/PMC13685630?pdf=render",
  "pmcid": "PMC13685630",
  "pmid": "42910189",
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bvx61eacbpmrh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910189",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910189"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2406|HIV Research and Treatment",
      "subfield": "microbiology"
    }
  ],
  "title": "Viral heritability of neurocognitive performances in persons living with HIV and underlying viral residue variants.",
  "title_text": "Viral heritability of neurocognitive performances in persons living with HIV and underlying viral residue variants.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/bvx61eacbpmrh",
  "venue": "Brain communications",
  "versions": []
}