{
  "abstract": "Mitral valve disease occurs in rheumatic heart disease (RHD) and selected systemic autoimmune rheumatic diseases, but similar lesions may have different underlying mechanisms. This structured narrative review examines epidemiological, mechanistic, imaging, and management evidence, distinguishing established pathways from incompletely validated mechanisms and hypotheses. In RHD, post-streptococcal valvulitis leads to fibrotic remodeling, commissural fusion, and chordal shortening, producing mitral stenosis, regurgitation, or mixed disease. A meta-analysis of 215,552 children and adolescents in endemic settings reported echocardiographically detected RHD in 24 per 1000. In systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), typical findings include leaflet thickening, Libman–Sacks vegetations, and regurgitation; embolic complications may occur despite mild valve dysfunction. Among 508 clinically selected patients with SLE undergoing echocardiography, 27.4% had heart valve involvement and 11.2% had mitral involvement. Immunothrombotic mechanisms may contribute to these lesions, but direct validation in human valve tissue remains incomplete. In rheumatoid arthritis (RA), a prospective cohort found an association with incident mitral regurgitation (adjusted hazard ratio 1.54, 95% confidence interval 1.32–1.81), but not mitral stenosis. Myocardial imaging findings do not establish a causal link to regurgitation. These findings support anatomy- and severity-based assessment in RHD, combined valvular and thromboembolic evaluation in SLE/APS, and assessment of conventional regurgitation mechanisms in RA. The framework informs clinical interpretation within existing guidelines, while proposed disease-specific mechanisms require further validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department and Clinic of Cardiology, Poznan University of Medical Sciences, Poznań, Poland",
    "Department of Rheumatology, Rehabilitation and Internal Diseases, Poznan University of Medical Sciences, Poznań, 61- 545 Poland",
    "Clinical Rehabilitation Laboratory, Department of Rehabilitation and Physiotherapy, Poznan University of Medical Sciences, Poznań, 60-545 Poland"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mateusz Lucki",
      "orcid": "0000-0002-6788-6067"
    },
    {
      "affs": [
        1
      ],
      "name": "Bogna Grygiel-Górniak",
      "orcid": "0000-0002-3438-0764"
    },
    {
      "affs": [
        2
      ],
      "name": "Ewa Lucka",
      "orcid": "0000-0002-8248-2247"
    },
    {
      "affs": [
        0
      ],
      "name": "Maciej Lesiak"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bw2p2qx6ae2a7.bib",
  "cited_by": 0,
  "doi": "10.1007/s00296-026-06345-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13740100/",
  "id": "bw2p2qx6ae2a7",
  "issns": [
    "0172-8172",
    "1437-160X"
  ],
  "landing_url": "https://doi.org/10.1007/s00296-026-06345-4",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7225335629",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00296-026-06345-4.pdf",
  "pmcid": "PMC13740100",
  "pmid": "42986448",
  "published": "2026-11-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bw2p2qx6ae2a7.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:21:24Z",
      "native_id": "PMC13740100",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00296-026-06345-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Mitral valve disease in rheumatic heart disease, systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid Arthritis",
  "title_text": "Mitral valve disease in rheumatic heart disease, systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid Arthritis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:21:24Z",
  "url": "https://research.draconitic.com/paper/bw2p2qx6ae2a7",
  "venue": "Rheumatology International",
  "versions": []
}