{
  "abstract": "Bidirectional crosstalk between metabolic reprogramming and extracellular matrix (ECM) remodeling in hepatocellular carcinoma (HCC) constitutes an important metabolic–ECM regulatory network that contributes to HCC progression. Metabolic derangements disrupt ECM deposition, crosslinking, and matrix mechanical properties, with downstream consequences for tumor invasion, immune evasion, and the establishment of pre-metastatic niches. Matrix remodeling in turn provides feedback via mechanotransduction and associated signaling networks that reprogram tumor cell glycolysis, lipogenesis, and amino acid metabolism, thereby forming a self-reinforcing malignant cycle. The network hubs in this cycle may represent candidate mechanobiological biomarkers for future patient stratification and longitudinal response monitoring, although their diagnostic and prognostic utility requires further clinical validation. Interventions are therefore shifting from single-target therapeutics toward coordinated, multi-node modulation aimed at decoupling the metabolic–ECM axis, including integrin-directed therapeutics combined with those that increase tumor microenvironment permeability; focal adhesion kinase (FAK) inhibitors, including those that disrupt functional coupling to epigenetic regulation; and the use of these regimens combined with anti-angiogenic agents, immunotherapies, or metabolic inhibitors to concurrently attenuate drug delivery barriers, mechanically driven cues, and metabolic plasticity. Collectively, therapeutic strategies aimed at decoupling the metabolic–ECM axis hold translational promise for limiting HCC progression, invasion, and metastasis, but their potential to improve long-term survival remains to be validated in clinical studies.",
  "abstract_shown": true,
  "affiliations": [
    "Hepatopancreatobiliary Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830011 China",
    "Hepato-Pancreato-Biliary Center, Key Laboratory of Digital Intelligence Hepatology (Ministry of Education), School of Clinical Medicine, Tsinghua Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, 102218 China",
    "School of Future Medicine, Beijing University of Chinese Medicine, Beijing, 100102 China",
    "Institute for Organ Transplant and Bionic Medicine, Beijing Key Laboratory of Liver Transplantation and Bionic Manufacturing, Tsinghua University, Beijing, 102218 China",
    "School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 China",
    "Center of Clinical Immunology, Peking University People’s Hospital, Peking University, Beijing, 100044 China",
    "Department of General Surgery, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Shandong University, Qingdao, 266035 China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
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        1
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      "name": "Yusufukadier Maimaitinijiati"
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    {
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        3,
        4
      ],
      "name": "Tanqing Long"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan Meng"
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    {
      "affs": [
        0
      ],
      "name": "Xiong Chen"
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    {
      "affs": [
        5
      ],
      "name": "Xiaoyan Xing"
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    {
      "affs": [
        6
      ],
      "name": "Zhihua Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingcai Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Qi Wang"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Juan Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bwaq7a522940b.bib",
  "cited_by": 1,
  "doi": "10.1186/s12964-026-03134-1",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737648/",
  "id": "bwaq7a522940b",
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  "landing_url": "https://doi.org/10.1186/s12964-026-03134-1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
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      "openalex",
      "1307|Cellular Mechanics and Interactions"
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  "openalex": "W7202039484",
  "pdf_url": null,
  "pmcid": "PMC13737648",
  "pmid": "42983536",
  "published": "2026-08-10",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/bwaq7a522940b.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:47Z",
      "native_id": "PMC13737648",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12964-026-03134-1"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Cellular Mechanics and Interactions",
      "subfield": "cell-biology"
    }
  ],
  "title": "Metabolic-extracellular matrix crosstalk in hepatocellular carcinoma: mechanisms and targeted intervention",
  "title_text": "Metabolic-extracellular matrix crosstalk in hepatocellular carcinoma: mechanisms and targeted intervention",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:47Z",
  "url": "https://research.draconitic.com/paper/bwaq7a522940b",
  "venue": "Cell Communication and Signaling : CCS",
  "versions": []
}