{
  "abstract": "Human nucleoli are multivalent, involving contributions from up to 10 NOR-bearing acrocentric chromosome p-arms. Precision megabase-scale chromosome engineering defines the requirements for this major genome organizational event. NOR deletions reveal that p-arm clustering can occur independent of rDNA. Deletion of all NOR-distal or NOR-proximal sequences individually have only a marginal effect on nucleolar association. Finally, deletion of an entire p-arm, while leaving centromere function intact, destroys the nucleolar association potential of that acrocentric. We propose that formation of multivalent nucleoli is not a nucleolar fusion event per se; rather it is driven by the surrounding chromosomal context of NORs.",
  "abstract_shown": true,
  "affiliations": [
    "Centre for Chromosome Biology, College of Science and Engineering, University of Galway, Galway H91 W2TY, Ireland"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Krystyna Giemza",
      "orcid": "0000-0002-7443-9417"
    },
    {
      "affs": [
        0
      ],
      "name": "Hazel Mangan"
    },
    {
      "affs": [
        0
      ],
      "name": "Brian McStay",
      "orcid": "0000-0002-5664-7781"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bwqt0xj800gcf.bib",
  "cited_by": 0,
  "doi": "10.1101/gad.354012.126",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13726607/",
  "id": "bwqt0xj800gcf",
  "issns": [
    "0890-9369",
    "1549-5477"
  ],
  "landing_url": "https://doi.org/10.1101/gad.354012.126",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Communication"
    ],
    [
      "openalex",
      "1110|Chromosomal and Genetic Variations"
    ]
  ],
  "openalex": "W7163915739",
  "pdf_url": "http://genesdev.cshlp.org/content/early/2026/08/20/gad.354012.126.full.pdf",
  "pmcid": "PMC13726607",
  "pmid": "42629160",
  "published": "2026-11-01",
  "publisher": "Cold Spring Harbor Laboratory Press",
  "ris": "https://research.draconitic.com/paper/bwqt0xj800gcf.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:22:54Z",
      "native_id": "PMC13726607",
      "source": "pmc",
      "url": "https://doi.org/10.1101/gad.354012.126"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Chromosomal and Genetic Variations",
      "subfield": "plant-biology"
    }
  ],
  "title": "Chromosomal requirements for formation of multivalent human nucleoli",
  "title_text": "Chromosomal requirements for formation of multivalent human nucleoli",
  "type": "preprint",
  "updated_at": "2026-11-06T12:22:31Z",
  "url": "https://research.draconitic.com/paper/bwqt0xj800gcf",
  "venue": "Genes & Development",
  "versions": []
}