{
  "abstract": "Background: Large‐volume paracentesis is the standard treatment for refractory ascites, but conventional angiocatheter (CA) use may be limited by kinking and dislodgement. KARAHOC (KH) is a multifenestrated over‐the‐needle catheter with an anchoring disc designed to improve catheter stability. We compared the efficacy and safety of KH with CA in cirrhotic patients with refractory ascites.\n\nMethods: This prospective, multicenter, 2 × 2 randomized crossover trial enrolled 87 cirrhotic patients requiring repeated paracentesis at three Korean academic hospitals. Participants underwent paracentesis with both KH and CA in randomized order at least 7 days apart. Successful paracentesis was defined as drainage of ≥ 3 L of ascites. Patient and operator satisfaction were assessed using a visual analog scale.\n\nResults: In the intention‐to‐treat analysis, success was higher with KH than with CA (87.5% vs. 71.6%; OR 2.78, 95% CI 1.22–6.30; p = 0.018), with shorter median procedure time (71 vs. 80 min; p = 0.018). Per‐protocol analysis showed similar results (91.9% vs. 77.0%; p = 0.015). Re‐puncture was less frequent with KH but was not statistically significant. Patient and operator satisfaction were significantly higher with KH (both p < 0.001). Adverse events were comparable, with no major complications.\n\nConclusion: KH improved paracentesis success, shortened procedure time, and increased satisfaction without compromising safety, supporting its use as a practical alternative to CA for repeated paracentesis in refractory ascites.\n\nTrial Registration: ClinicalTrials.gov: NCT05578573",
  "abstract_shown": true,
  "affiliations": [
    "Division of Gastroenterology and Hepatology, Department of Internal Medicine Soonchunhyang University Bucheon Hospital Bucheon Republic of Korea",
    "Department of Internal Medicine Inje University Haeundae Paik Hospital Busan Republic of Korea",
    "Department of Internal Medicine Korea University Anam Hospital Seoul Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "So Hyun Jeon",
      "orcid": "0009-0001-1653-5806"
    },
    {
      "affs": [
        1
      ],
      "name": "Nae‐Yun Heo"
    },
    {
      "affs": [
        0
      ],
      "name": "Seon Ah. Maeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Hae won Yoo",
      "orcid": "0000-0001-5086-5385"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeong‐Ju Yoo",
      "orcid": "0000-0002-7802-0381"
    },
    {
      "affs": [
        0
      ],
      "name": "Young Seok Kim",
      "orcid": "0000-0002-7113-3623"
    },
    {
      "affs": [
        1
      ],
      "name": "Seung Ha Park"
    },
    {
      "affs": [
        2
      ],
      "name": "Yeon Seok Seo"
    },
    {
      "affs": [
        0
      ],
      "name": "Sang Gyune Kim",
      "orcid": "0000-0001-8694-777X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bx4gqfd869sme.bib",
  "cited_by": 0,
  "doi": "10.1111/jgh.70716",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731055/",
  "id": "bx4gqfd869sme",
  "issns": [
    "0815-9319",
    "1440-1746"
  ],
  "landing_url": "https://doi.org/10.1111/jgh.70716",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article ‐ Hepatology (Clinical)"
    ],
    [
      "openalex",
      "2721|Liver Disease and Transplantation"
    ]
  ],
  "openalex": "W7208745497",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgh.70716",
  "pmcid": "PMC13731055",
  "pmid": "42693590",
  "published": "2026-09-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bx4gqfd869sme.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:19Z",
      "native_id": "PMC13731055",
      "source": "pmc",
      "url": "https://doi.org/10.1111/jgh.70716"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver Disease and Transplantation",
      "subfield": "general"
    }
  ],
  "title": "A Novel Anchoring Catheter Improves the Success, Efficiency, and Satisfaction of Paracentesis in Refractory Ascites: A Multicenter Randomized Crossover Trial",
  "title_text": "A Novel Anchoring Catheter Improves the Success, Efficiency, and Satisfaction of Paracentesis in Refractory Ascites: A Multicenter Randomized Crossover Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:19Z",
  "url": "https://research.draconitic.com/paper/bx4gqfd869sme",
  "venue": "Journal of Gastroenterology and Hepatology",
  "versions": []
}