{
  "abstract": "Background: Early invasive aspergillosis (IA) is a severe complication of liver transplantation, but data from Chinese recipients remain limited. We evaluated its clinical characteristics, outcomes, and independent predictors. Methods: We retrospectively studied adult liver transplant recipients at the First Affiliated Hospital of Zhejiang University from August 2018 to March 2023. Patients meeting 2020 EORTC/MSGERC criteria for proven or probable IA within 1 month post-transplant were matched 1:2 to non-IA controls by age, sex, and etiology. Postoperative intensive care unit and intubation durations were excluded from multivariable regression to eliminate temporal bias. Results: Among 1051 recipients, 78 developed early IA (7.4% incidence; 3 proven, 75 probable), matched to 156 controls. Aspergillus fumigatus predominated (64.1%), with a median onset of 5 days. IA was associated with reduced 12-month survival (65.4% vs 80.1%, P = 0.014). Higher acute-on-chronic liver failure (ACLF) grade, preoperative corticosteroid exposure, and postoperative 12-hour lactate >5 mmol/L were independent risk factors. Conclusion: ACLF severity, pretransplant corticosteroids, and early postoperative hyperlactatemia independently correlate with early IA. These hypothesis-generating findings help identify high-risk recipients requiring targeted surveillance.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Liver Transplant Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China",
    "Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuntao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zongyan Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Pingbo Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Shichao Shen"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Junfang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yue Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Rongrong Wang"
    },
    {
      "name": "Tingbo Liang"
    },
    {
      "name": "Wei Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bx6ghwcz4axkz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijid.2026.109206",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S1201971226008416",
  "id": "bx6ghwcz4axkz",
  "issns": [
    "1201-9712",
    "1878-3511"
  ],
  "landing_url": "https://doi.org/10.1016/j.ijid.2026.109206",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC109-216"
    ],
    [
      "openalex",
      "2725|Antifungal resistance and susceptibility"
    ]
  ],
  "openalex": "W7223460709",
  "pdf_url": "https://www.ijidonline.com/article/S1201-9712(26)00841-6/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/bx6ghwcz4axkz.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T14:20:46Z",
      "native_id": "0a01eae170b94b4d82094ddc37ddadc7",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.ijid.2026.109206"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Antifungal resistance and susceptibility",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Early invasive aspergillosis after liver transplantation: a matched case–control analysis of clinical features and risk factors in a Chinese cohort",
  "title_text": "Early invasive aspergillosis after liver transplantation: a matched case–control analysis of clinical features and risk factors in a Chinese cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T14:20:10Z",
  "url": "https://research.draconitic.com/paper/bx6ghwcz4axkz",
  "venue": "International Journal of Infectious Diseases",
  "versions": []
}