{
  "abstract": "Background This correspondence is a commentary to the recently published report from the OSAN trial by Fiedorowicz et al. but with applicability to the broader research involving blue-blocking glasses and patients in a manic episode. Method Clinical studies on dark therapy are still rare, and we read with great interest the report from the OSAN trial published in Journal of Affective Disorders the 1st of April 2026. Results The sample was significantly higher in manic symptoms, more medicated and less adherent to the intervention than in preceding studies on effects of dark therapy for mania. Efforts to comply with the gold standard of blinding of raters may have come with the cost of underestimating the symptom level. Extended intervention period (2 weeks) may have caused the extensive loss to follow up (35/42 (83%) at 2 weeks). Several issues with the statistical methods and data reporting make the results difficult to interpret. Conclusions The statistical power of the OSAN trial may have been substantially reduced by attrition and multiple sources of variance to the data. The results from the trial should be interpreted with caution.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Mental Health Care, Valen Hospital, Fonna Hospital Trust",
    "Department of Research and Innovation, Fonna Hospital Trust",
    "Division of Neuroscience, IRCCS Ospedale San Raffaele",
    "Psychiatric Division, Stavanger University Hospital",
    "Division of Psychiatry, Haukeland University Hospital",
    "Département de psychiatrie et d’addictologie, GHU Paris Nord, DMU Neurosciences NeuroDiderot, AP-HP, Université Paris Cité",
    "Chicago Psychiatry Associates",
    "Department of Mental Health, Norwegian University of Science and Technology",
    "DepressionEducation.org",
    "Mental Health Services Noord-Holland‐Noord",
    "Department of Clinical Science, Faculty of Medicine, University of Bergen"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tone Elise Gjøtterud Henriksen"
    },
    {
      "affs": [
        1
      ],
      "name": "Jörg Assmus"
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    {
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        2
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      "name": "Barbara Barbini"
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    {
      "affs": [
        2
      ],
      "name": "Francesco Benedetti"
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    {
      "affs": [
        3
      ],
      "name": "Jeanette Solheimslid Bjørke"
    },
    {
      "affs": [
        4
      ],
      "name": "Ole Bernt Fasmer"
    },
    {
      "affs": [
        5
      ],
      "name": "Pierre Alexis Geoffroy"
    },
    {
      "affs": [
        6
      ],
      "name": "John Gottlieb"
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    {
      "affs": [
        7
      ],
      "name": "Håvard Kallestad"
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    {
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        8
      ],
      "name": "James Phelps"
    },
    {
      "affs": [
        4
      ],
      "name": "Ieva Ratke"
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    {
      "affs": [
        9
      ],
      "name": "Peter F.J. Schulte"
    },
    {
      "affs": [
        10
      ],
      "name": "Silje Skrede"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bxby8jm0z2wmn.bib",
  "cited_by": 0,
  "doi": "10.1186/s40345-026-00446-6",
  "fulltext_url": "https://doi.org/10.1186/s40345-026-00446-6",
  "id": "bxby8jm0z2wmn",
  "issns": [
    "2194-7511"
  ],
  "landing_url": "https://doi.org/10.1186/s40345-026-00446-6",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QP351-495"
    ],
    [
      "lcc",
      "RC321-571"
    ],
    [
      "openalex",
      "2738|Bipolar Disorder and Treatment"
    ]
  ],
  "openalex": "W7223009644",
  "pdf_url": "https://link.springer.com/content/pdf/10.1186/s40345-026-00446-6.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "SpringerOpen",
  "ris": "https://research.draconitic.com/paper/bxby8jm0z2wmn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:36Z",
      "native_id": "95cca63debaa48dd9d64542783f793f1",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s40345-026-00446-6"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Bipolar Disorder and Treatment",
      "subfield": "psychiatry"
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  ],
  "title": "Methodological concerns limiting the detection of treatment effects in the OSAN trial of blue-blocking glasses for mania",
  "title_text": "Methodological concerns limiting the detection of treatment effects in the OSAN trial of blue-blocking glasses for mania",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:36Z",
  "url": "https://research.draconitic.com/paper/bxby8jm0z2wmn",
  "venue": "International Journal of Bipolar Disorders",
  "versions": []
}