{
  "abstract": "Survival and transmission of the human pathogen Trypanosoma cruzi depend on dynamic remodeling of its membrane proteome, yet the post-translational networks governing this plasticity remain obscure. Using metabolic labeling and quantitative mass spectrometry, we present a comprehensive map of the T. cruzi S-palmitoylome: a high-confidence atlas of 254 proteins enriched for signaling factors, cytoskeletal regulators, and membrane transporters. Functional screening with our aptazyme-based SHARK knockdown system identifies ABCA10, an uncharacterized ABC transporter central to heme homeostasis. Depletion of ABCA10 triggers a compensatory surge in cytostome-mediated endocytosis, rendering this normally dispensable process conditionally essential. ABCA10 expression is itself heme-regulated and upon heme starvation it redistributes from the flagellar pocket to pre-lysosomal reservosomes. We further show that endocytosis is directly tuned by extracellular heme, placing the entire uptake apparatus, not only ABCA10, under heme-responsive control. Together, these findings reveal a redundant heme-scavenging strategy and expose a druggable vulnerability in a neglected pathogen.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA USA",
    "Department of Cellular Biology, University of Georgia, Athens, GA USA",
    "Department of Biomedical Sciences, Florida State University, Tallahassee, FL USA",
    "Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Universidad Nacional de Rosario (UNR), Rosario, Argentina",
    "Área Biofísica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Rosario, Argentina"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Gonzalo Seminario-Mondejar",
      "orcid": "0000-0001-8657-0343"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Menna Etheridge"
    },
    {
      "affs": [
        2
      ],
      "name": "Anthony A. Ruberto",
      "orcid": "0000-0002-3215-9484"
    },
    {
      "affs": [
        1
      ],
      "name": "Susan Phan"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Julia Alejandra Cricco"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ronald Drew Etheridge"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bxd3nf50r6ndc.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77828-y",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710745/",
  "id": "bxd3nf50r6ndc",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-77828-y",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2713|Trypanosoma species research and implications"
    ]
  ],
  "openalex": "W7214210790",
  "pdf_url": "https://www.nature.com/articles/s41467-026-77828-y_reference.pdf",
  "pmcid": "PMC13710745",
  "pmid": "42934222",
  "published": "2026-09-24",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/bxd3nf50r6ndc.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:39Z",
      "native_id": "PMC13710745",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-77828-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Trypanosoma species research and implications",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "A global S-palmitoylation map of Trypanosoma cruzi identifies ABCA10 as a key component of a redundant heme-acquisition system",
  "title_text": "A global S-palmitoylation map of Trypanosoma cruzi identifies ABCA10 as a key component of a redundant heme-acquisition system",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:39Z",
  "url": "https://research.draconitic.com/paper/bxd3nf50r6ndc",
  "venue": "Nature Communications",
  "versions": []
}