{
  "abstract": "SUMMARY: OBJECTIVE:: The aim of this study was to evaluate changes in inflammatory markers after cardiac surgery with cardiopulmonary bypass and assess the discriminatory ability of aortic cross-clamp time for postoperative acute kidney injury.\n\nMETHODS:: This retrospective single-center study included 109 patients undergoing cardiopulmonary bypass-assisted cardiac surgery between January 2024 and March 2025. Preoperative and postoperative (30–36 h) creatinine, urea, albumin, C-reactive protein, neutrophil, and lymphocyte levels were evaluated. Acute kidney injury was defined using the serum creatinine component of KDIGO criteria. C-reactive protein/albumin ratio, C-reactive protein/lymphocyte ratio, neutrophil/lymphocyte ratio, and albumin×lymphocyte/C-reactive protein (CALLY) were calculated. Given the limited number of acute kidney injury cases, analyses were exploratory. Aortic cross-clamp time was assessed by receiver operating characteristic analysis.\n\nRESULTS:: Postoperative neutrophil, lymphocyte, and albumin levels differed significantly from preoperative values (all false discovery rate-corrected p<0.001). C-reactive protein, C-reactive protein/albumin ratio, C-reactive protein/lymphocyte ratio, neutrophil/lymphocyte ratio, and CALLY levels increased significantly (all false discovery rate-corrected p<0.001). Acute kidney injury developed in 15 patients and was more common among non-survivors (10.1 vs. 50.0%; p=0.006; false discovery rate-corrected p=0.022). Postoperative creatinine levels were higher in non-survivors (false discovery rate-corrected p=0.011). Aortic cross-clamp time showed limited discrimination for Acute kidney injury (area under curve=0.621). At the 52-min cutoff, sensitivity was 66.7%, and specificity was 60.2%.\n\nCONCLUSION:: Cardiopulmonary bypass-associated cardiac surgery was accompanied by significant inflammatory changes. Aortic cross-clamp time showed limited discriminatory ability and should be considered an exploratory risk indicator rather than a standalone predictor of acute kidney injury.",
  "abstract_shown": true,
  "affiliations": [
    "Harran University, Faculty of Health Sciences, Department of Perfusion – Şanlıurfa, Türkiye.",
    "Harran University, Research and Application Hospital, Department of Cardiovascular Surgery – Şanlıurfa, Türkiye.",
    "Harran University, Vocational School of Health Services, Dialysis Programme – Şanlıurfa, Türkiye.",
    "Ministry of Health, Ordu State Hospital, Department of Cardiovascular Surgery – Ordu, Türkiye"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yasemin Hacanlı",
      "orcid": "0000-0002-4427-8149"
    },
    {
      "affs": [
        1
      ],
      "name": "Murat Ziya Bağiş",
      "orcid": "0000-0002-4088-7510"
    },
    {
      "affs": [
        0
      ],
      "name": "Mahmut Padak",
      "orcid": "0000-0001-6863-1907"
    },
    {
      "affs": [
        0
      ],
      "name": "Ömer Göç",
      "orcid": "0000-0002-3047-6232"
    },
    {
      "affs": [
        2
      ],
      "name": "Kadir Egi",
      "orcid": "0000-0003-4802-0994"
    },
    {
      "affs": [
        3
      ],
      "name": "Mehmet Burak Coşkun",
      "orcid": "0000-0001-6748-575X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bxnkx56k9g1w9.bib",
  "cited_by": 0,
  "doi": "10.1590/1806-9282.20260819",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722090/?tool=EBI",
  "id": "bxnkx56k9g1w9",
  "issns": [
    "0104-4230",
    "1806-9282"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13722090",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2746|Cardiac and Coronary Surgery Techniques"
    ]
  ],
  "openalex": "W7224945098",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722090/pdf/?tool=EBI",
  "pmcid": "PMC13722090",
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Associação Médica Brasileira",
  "ris": "https://research.draconitic.com/paper/bxnkx56k9g1w9.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13722090",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722090"
    },
    {
      "first_seen": "2026-11-03T12:22:40Z",
      "native_id": "PMC13722090",
      "source": "pmc",
      "url": "https://doi.org/10.1590/1806-9282.20260819"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cardiac and Coronary Surgery Techniques",
      "subfield": "surgery"
    }
  ],
  "title": "Cardiopulmonary bypass time, inflammatory response, and acute kidney injury in cardiac surgery: a retrospective study",
  "title_text": "Cardiopulmonary bypass time, inflammatory response, and acute kidney injury in cardiac surgery: a retrospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:40Z",
  "url": "https://research.draconitic.com/paper/bxnkx56k9g1w9",
  "venue": "Revista da Associacao Medica Brasileira (1992)",
  "versions": []
}