{
  "abstract": "Background: Ceiba pentandra (L.) Gaertn stem bark is used traditionally for reproductive and inflammatory disorders, but its estrogenic and anti-prostatitis activities lack scientific validation.Objective: To evaluate the phytochemical constituents, estrogenic activity, and anti-inflammatory potential of C. pentandra aqueous stem-bark extract (AECP) in Wistar rats. Methods: Phytochemical screening used standard assays. Estrogenic activity was evaluated via the 3-day OECD 440 uterotrophic bioassay in ovariectomized rats (200 and 400 mg/kg/day p.o. vs. 17β-estradiol 10 µg/kg). Anti-inflammatory efficacy was assessed in male rats with intraprostatic carrageenan-induced prostatitis (200, 400, and 600 mg/kg p.o. vs. diclofenac 5 mg/kg), determining prostatic index and hematology at 24 h. Results: AECP contained polyphenols, tannins, flavonoids, saponins, and triterpenes/steroids (alkaloids absent). In ovariectomized rats, AECP (400 mg/kg) significantly increased relative uterine weight from 0.0418 ± 0.0026% to 0.0676 ± 0.0080% (p<0.02; +61.7%) without adrenal hypertrophy. In prostatitis, AECP (400 and 600 mg/kg) reduced the carrageenan-elevated prostatic index from 4.212 to 2.850 and 2.649 mg/g (p<0.001), comparable to diclofenac (2.318 mg/g). AECP (600 mg/kg) also normalized leukocytosis (from 9.967 to 3.400 × 10³/µL). Conclusion: AECP exhibits significant estrogenic and anti-prostatitis activities in Wistar rats, validating its traditional medicinal use.",
  "abstract_shown": true,
  "affiliations": [
    "Animal Physiology Laboratory, Department of Animal Biology and Physiology, University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Basile Tindano"
    },
    {
      "affs": [
        0
      ],
      "name": "Nathalie Ouedraogo"
    },
    {
      "affs": [
        0
      ],
      "name": "Maya Doukouré"
    },
    {
      "affs": [
        0
      ],
      "name": "Elisabeth Ouedraogo"
    },
    {
      "affs": [
        0
      ],
      "name": "Abdelaziz Koussoubé"
    },
    {
      "affs": [
        0
      ],
      "name": "Filkpièrè Léonard Da"
    },
    {
      "affs": [
        0
      ],
      "name": "Balé Bayala"
    },
    {
      "affs": [
        0
      ],
      "name": "G Raymond Belemtougri G Raymond Belemtougri"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bxp1cdyhremz8.bib",
  "cited_by": 0,
  "doi": "10.26452/ijrps.v17i3.4421",
  "fulltext_url": "https://ijrps.com/v17i3/4421",
  "id": "bxp1cdyhremz8",
  "issns": [
    "0975-7538"
  ],
  "landing_url": "https://doi.org/10.26452/ijrps.v17i3.4421",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "HD9665-9675"
    ],
    [
      "lcc",
      "RS1-441"
    ],
    [
      "openalex",
      "1110|Medicinal Plant Research"
    ]
  ],
  "openalex": "W7204171820",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "JK Welfare & Pharmascope Foundation",
  "ris": "https://research.draconitic.com/paper/bxp1cdyhremz8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:07Z",
      "native_id": "eccc7c06a9b6493fa5887755e561684f",
      "source": "doaj",
      "url": "https://doi.org/10.26452/ijrps.v17i3.4421"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Medicinal Plant Research",
      "subfield": "plant-biology"
    }
  ],
  "title": "Estrogenic and Anti-prostatitis Activities of Ceiba pentandra (L.) Gaertn (Malvaceae) Stem Bark Aqueous Extract in Wistar Rats",
  "title_text": "Estrogenic and Anti-prostatitis Activities of Ceiba pentandra (L.) Gaertn (Malvaceae) Stem Bark Aqueous Extract in Wistar Rats",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:07Z",
  "url": "https://research.draconitic.com/paper/bxp1cdyhremz8",
  "venue": "International Journal of Research in Pharmaceutical Sciences",
  "versions": []
}