{
  "abstract": "Background: Depression is increasingly viewed as a progressive neurobiological trajectory, yet the spatiotemporal transition from early mood dysregulation to chronic network failure, and its relation to disease-related functional decline, remains unclear. Using a chronic unpredictable mild stress (CUMS) mouse model, we aimed to map the longitudinal brain transformation from local spontaneous activity to global network dysfunction via multi-parametric MRI.\n\nMethods: Longitudinal functional magnetic resonance imaging (fMRI) was performed on a cohort of CUMS mice (n = 7) across three longitudinal time points: Day 0 (baseline), Day 5 CUMS, and Day 10 CUMS. We integrated four analytical approaches: fALFF, static functional connectivity, graph theory, and dFC/dALFF.\n\nResults: Depression progression followed a hierarchical spatiotemporal dissolution. fALFF revealed sequential breakdown of local hubs in caudoputamen, medial prefrontal cortex, and hippocampus, suggesting involvement of motor-motivational and executive deficits. sFC showed sensory-limbic uncoupling between caudoputamen and visual areas, and altered mPFC-AON connectivity and hippocampal prefrontal (HPF-PL) dysconnectivity, indicating limbic-olfactory loop disruption. Graph theory indicated preserved global node efficiency but widespread loss of node local efficiency and clustering. Dynamic analyses uncovered a shift from flexible network reconfiguration to dynamic rigidity.\n\nConclusion: Longitudinal CUMS exposure was associated with progressive alterations in functional network organization. The prefrontal olfactory dysconnectivity and onset of dynamic rigidity represent candidate multi-scale and longitudinal imaging features that warrant future validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Systems Science, Faculty of Arts and Sciences, Beijing Normal University",
    "International Academic Center of Complex Systems, Beijing Normal University",
    "School of Systems Science, Beijing Normal University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
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        0,
        1,
        2
      ],
      "name": "Yu Yang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Huixia Jia"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "He Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/by46q99tq3466.bib",
  "cited_by": 0,
  "doi": "10.3389/fpsyt.2026.1898694",
  "fulltext_url": "https://europepmc.org/articles/PMC13714589",
  "id": "by46q99tq3466",
  "issns": [
    "1664-0640"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1898694/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
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      "openalex",
      "2805|Functional Brain Connectivity Studies"
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  "openalex": "W7221830185",
  "pdf_url": "https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1898694/pdf",
  "pmcid": "PMC13714589",
  "pmid": "42953085",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/by46q99tq3466.ris",
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    {
      "first_seen": "2026-10-30T12:20:18Z",
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      "url": "https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1898694/full"
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    {
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      "url": "https://doi.org/10.3389/fpsyt.2026.1898694"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Functional Brain Connectivity Studies",
      "subfield": "neuroscience"
    }
  ],
  "title": "Neuroprogression of chronic stress-induced depression via longitudinal fMRI",
  "title_text": "Neuroprogression of chronic stress-induced depression via longitudinal fMRI",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:03Z",
  "url": "https://research.draconitic.com/paper/by46q99tq3466",
  "venue": "Frontiers in Psychiatry",
  "versions": []
}