{
  "abstract": "Ketogenic diets have been proposed as potential neuroprotective interventions for Parkinson’s disease (PD), but concerns remain regarding their effects on the gut microbiome and gut-brain-immune axis. We conducted a randomized crossover trial comparing 8-week Mediterranean-ketogenic (MeDi-KD) versus medium-chain triglyceride-supplemented Mediterranean (MeDi-MCT) diets, separated by an 8-week washout (NCT05469997). Primary outcomes included changes in gut microbiome taxonomic and functional profiles, fecal short-chain fatty acid (SCFA) production, and biomarkers of intestinal permeability and inflammation. Neither intervention significantly altered microbiome diversity or functional gene abundance, established features of PD-associated dysbiosis, nor fecal or plasma biomarkers of intestinal permeability (zonulin) or inflammation (calprotectin). The MeDi-KD modestly reduced total fecal SCFAs, while both interventions increased the relative abundance of Roseburia hominis, and the MeDi-MCT was associated with decreases in plasma IL-1β and IL-8. No severe adverse events were reported, supporting further investigation of MeDi-KD strategies in larger, longer-duration PD trials.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Kira Tosefsky",
      "orcid": "0000-0002-8483-8980"
    },
    {
      "name": "Samantha L. Schaffner"
    },
    {
      "name": "Joyce S.T. Lam"
    },
    {
      "name": "Yolanda N. Wang"
    },
    {
      "name": "Shayan Keymanesh"
    },
    {
      "name": "Annie J. Kuan"
    },
    {
      "name": "Avril Metcalfe-Roach"
    },
    {
      "name": "Mihai S. Cirstea"
    },
    {
      "name": "Matthew A. Sacheli"
    },
    {
      "name": "Tessa F. Morelli"
    },
    {
      "name": "Matthew Yap"
    },
    {
      "name": "Olivia Brigden"
    },
    {
      "name": "Madison Gill"
    },
    {
      "name": "Tamara R. Cohen"
    },
    {
      "name": "Sophie Stukas"
    },
    {
      "name": "B. Brett Finlay"
    },
    {
      "name": "Silke Appel-Cresswell",
      "orcid": "0000-0002-5986-1468"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bybnw6jvgbj2z.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117981",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738181/",
  "id": "bybnw6jvgbj2z",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03364-X",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Diet"
    ],
    [
      "heading",
      "Interventions"
    ],
    [
      "heading",
      "Microbial genomics"
    ],
    [
      "openalex",
      "2737|Diet and metabolism studies"
    ]
  ],
  "openalex": "W7224128576",
  "pdf_url": null,
  "pmcid": "PMC13738181",
  "pmid": "42992162",
  "published": "2026-10-28",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/bybnw6jvgbj2z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117981",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03364-X"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117981",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S258900422603364X"
    },
    {
      "first_seen": "2026-11-09T12:23:13Z",
      "native_id": "PMC13738181",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.117981"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Diet and metabolism studies",
      "subfield": "physiology"
    }
  ],
  "title": "Mediterranean-ketogenic vs. medium-chain triglyceride supplemented Mediterranean diet: Effects on the gut-brain-immune axis in Parkinson’s disease",
  "title_text": "Mediterranean-ketogenic vs. medium-chain triglyceride supplemented Mediterranean diet: Effects on the gut-brain-immune axis in Parkinson’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:13Z",
  "url": "https://research.draconitic.com/paper/bybnw6jvgbj2z",
  "venue": "iScience",
  "versions": []
}