{
  "abstract": "Chronic osteomyelitis is difficult to treat due to the interplay of bacterial colonization, excessive inflammation, and impaired bone regeneration. Here, we developed an engineered natural polysaccharide POP@ZIF-67 nanoplatform to modulate these interrelated pathological processes. ZIF-67 is an antimicrobial framework with porous properties, peroxidase-like catalytic activity, and acid-responsive release behavior; purslane polysaccharide (POP) was incorporated as an immunomodulatory component to mitigate the excessive inflammatory stimulation induced by ZIF-67. POP@ZIF-67 exhibits effective antibacterial and antibiofilm activity against Staphylococcus aureus; more importantly, the incorporation of POP transforms the biological action of ZIF-67 from primarily antibacterial stimulation into a multifunctional platform capable of suppressing excessive M1-like macrophage responses, promoting repair-related polarization, and improving the osteogenic microenvironment. In a mouse model of chronic osteomyelitis, POP@ZIF-67 reduced local bacterial load and inflammatory damage while promoting collagen deposition, bone remodeling, and osteogenic maturation, without significant systemic toxicity. Overall, the study introduces an \"antimicrobial framework-immune buffering\" strategy that reconciles the antimicrobial efficacy of metal-organic frameworks with their immunostimulatory limitations. By integrating various therapeutic approaches, POP@ZIF-67 provides a promising new synthetic paradigm for the treatment of chronic osteomyelitis and infectious bone defects.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.",
    "Hubei Provincial Clinical Medical Research Center for Trauma and Microsurgery, Wuhan, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yunchang Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Guangting Zhu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mengxue Zhang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yize Wu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Junwei Su"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jing Hu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chao Jian"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ying Yuan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bym6vn0z4dzmx.bib",
  "cited_by": 0,
  "doi": "10.3389/fbioe.2026.1935416",
  "fulltext_url": "https://europepmc.org/articles/PMC13683671",
  "id": "bym6vn0z4dzmx",
  "issns": [
    "2296-4185"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909020",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Orthopedic Infections and Treatments"
    ]
  ],
  "openalex": "W7220840842",
  "pdf_url": "https://europepmc.org/articles/PMC13683671?pdf=render",
  "pmcid": "PMC13683671",
  "pmid": "42909020",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bym6vn0z4dzmx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909020",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909020"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Orthopedic Infections and Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Natural polysaccharide-engineered POP@ZIF-67 nanoparticles coordinate antibacterial activity, macrophage polarization, and osteogenesis for chronic osteomyelitis therapy.",
  "title_text": "Natural polysaccharide-engineered POP@ZIF-67 nanoparticles coordinate antibacterial activity, macrophage polarization, and osteogenesis for chronic osteomyelitis therapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/bym6vn0z4dzmx",
  "venue": "Frontiers in bioengineering and biotechnology",
  "versions": []
}