{
  "abstract": "Understanding the mechanisms responsible for intracellular heme regulation remains a significant challenge. Here, we use molecularly crowded condensate droplets to sequester heme-binding sensor proteins that are subsequently activated by the uptake of free heme from aqueous solution. We demonstrate competitive heme binding and heme-mediated signaling within the membraneless coacervate droplets, and construct programmable synthetic/living cell communication networks capable of concatenated Boolean logic functions. Our results indicate that coacervate microdroplets are potential scaffolds for housing heme-sensor networks and provide a simplified model for exploring how biomolecular condensates may influence heme availability in cellular environments.",
  "abstract_shown": true,
  "affiliations": [
    "Centre for Protolife Research and Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol Bristol BS8 1TS UK s.mann@bristol.ac.uk.",
    "Max Planck-Bristol Centre for Minimal Biology, School of Chemistry, University of Bristol Bristol BS8 1TS UK.",
    "School of Chemistry, University of Bristol Bristol BS8 1TS UK."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ananya Mishra",
      "orcid": "0000-0002-6852-1318"
    },
    {
      "affs": [
        2
      ],
      "name": "Andrea E Gallio",
      "orcid": "0000-0003-3094-681X"
    },
    {
      "affs": [
        2
      ],
      "name": "Emma L Raven",
      "orcid": "0000-0002-1643-8694"
    },
    {
      "affs": [
        0
      ],
      "name": "Avinash J Patil",
      "orcid": "0000-0002-1959-5310"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Stephen Mann",
      "orcid": "0000-0003-3012-8964"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/byn3g0z8a9tb3.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc06692e",
  "fulltext_url": "https://europepmc.org/articles/PMC13688254",
  "id": "byn3g0z8a9tb3",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923335",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Supramolecular Self-Assembly in Materials"
    ]
  ],
  "openalex": "W7223186005",
  "pdf_url": "https://europepmc.org/articles/PMC13688254?pdf=render",
  "pmcid": "PMC13688254",
  "pmid": "42923335",
  "published": "2026-10-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/byn3g0z8a9tb3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923335",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923335"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Supramolecular Self-Assembly in Materials",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Heme sequestration and signaling in molecular condensates.",
  "title_text": "Heme sequestration and signaling in molecular condensates.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/byn3g0z8a9tb3",
  "venue": "Chemical science",
  "versions": []
}