{
  "abstract": "Background\n\nDepression is the leading global cause of disability, yet dietary research has overlooked condiments as a concentrated, habitual exposure. Emulsified high-fat condiments may drive neuroinflammation independently of total caloric intake, offering a feasible prevention target, but their mental health impact remains unexamined.Methods\n\nThis study comprised two phases: (1) A cross-sectional analysis of 2423 adults from NHANES 2005-2006, examining associations between condiment intake frequency and PHQ-9 scores using negative binomial regression; (2) A zebrafish experiment where adult fish were exposed to 0%, 1%, 5%, or 10% mayonnaise for 4 weeks, followed by behavioral assessment and qPCR analysis of hub genes identified by network toxicology.Results\n\nIn NHANES, ≥3 times/week intake of sugar/honey (aRR = 1.22, 95%CI: 1.02-1.45), margarine (1.19, 1.01-1.41), butter (1.30, 1.09-1.55), and mayonnaise (1.37, 1.12-1.66) was associated with higher PHQ-9 scores (all P < 0.05). Mayonnaise showed the strongest association. In zebrafish, mayonnaise dose-dependently altered depression-like behaviors, including reduced top exploration and increased freezing time (P < 0.05). Network toxicology identified 81 shared targets between mayonnaise components (linoleic and elaidic acid) and depression, with PPARA, SRC, PTGS2, IL6, and ESR1 as central hubs. qPCR showed dose-dependent upregulation of ppara, ptgs2a, il6, and esr1 in zebrafish brain (P < 0.05).Conclusions\n\nMayonnaise and comparable emulsified high-fat condiments are independently associated with depressive symptoms, with amplified risk in specific vulnerable subgroups. Zebrafish behavioral and molecular data provide hypothesis-generating mechanistic plausibility. Targeted condiment reduction thus represents an actionable, low-barrier strategy for depression prevention.",
  "abstract_shown": true,
  "affiliations": [
    "Neurologic Department, The People's Hospital of Chongqing Liangping District, Chongqing, 405200, China.",
    "College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, 233030, China.",
    "Nanjing Simcere Medical Laboratory Science Co., Ltd., State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, 210042, China.",
    "Jiangsu Simcere Diagnostic Technology Co., Ltd., State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, 210042, China.",
    "Department of Anesthesiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhiping Yao"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuan Dong"
    },
    {
      "affs": [
        2
      ],
      "name": "Xuewen Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Dongsheng Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Xing Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Hui Peng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/byyw33dywsvpg.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bbrep.2026.102840",
  "fulltext_url": "https://europepmc.org/articles/PMC13685991",
  "id": "byyw33dywsvpg",
  "issns": [
    "2405-5808"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910290",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2803|Tryptophan and brain disorders"
    ]
  ],
  "openalex": "W7221713081",
  "pdf_url": "https://europepmc.org/articles/PMC13685991?pdf=render",
  "pmcid": "PMC13685991",
  "pmid": "42910290",
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/byyw33dywsvpg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42910290",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910290"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2803|Tryptophan and brain disorders",
      "subfield": "psychiatry"
    }
  ],
  "title": "Mayonnaise intake and depression: dose-response in humans and neurobehavioral and molecular mechanisms in zebrafish.",
  "title_text": "Mayonnaise intake and depression: dose-response in humans and neurobehavioral and molecular mechanisms in zebrafish.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/byyw33dywsvpg",
  "venue": "Biochemistry and biophysics reports",
  "versions": []
}