{
  "abstract": "Peptide-oligonucleotide conjugates can unite DNA nanotechnology with peptide self-assembly to create new and unusual nanostructures. We have created the first conjugate of DNA to a Waltz peptide – a class of β-sheet peptides which are important in the study of biological amyloids. Multi-micrometer rods have been identified which are attributable to peptide-dominated assembly. These results could lead to new ways to interface with amyloid, as well as demonstrating the range of self-assembled structures possible with DNA-peptide conjugates.",
  "abstract_shown": true,
  "affiliations": [
    "UCL School of Pharmacy, 29-39 Brunswick Square, London, UK, WC1N 1AX",
    "School of Chemistry and Forensic Science, University of Kent, Ingram Building, Canterbury, Kent, UK, CT2 7NH",
    "School of Biosciences, University of Kent, Stacey Building, Canterbury, Kent, UK, CT2 7NJ",
    "Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Wӓhringer Straße. 42, Vienna, Austria, 1090"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Henry W. Rose"
    },
    {
      "affs": [
        1
      ],
      "name": "Akiko Sato"
    },
    {
      "affs": [
        1
      ],
      "name": "Isobel Jones"
    },
    {
      "affs": [
        1
      ],
      "name": "Emerald R. Taylor"
    },
    {
      "affs": [
        0
      ],
      "name": "Findley R. Morgan"
    },
    {
      "affs": [
        0
      ],
      "name": "Takeru Dannoue"
    },
    {
      "affs": [
        2
      ],
      "name": "David M. Beal"
    },
    {
      "affs": [
        3
      ],
      "name": "Michael R. Reithofer"
    },
    {
      "affs": [
        0
      ],
      "name": "Christopher J. Serpell",
      "orcid": "0000-0002-2848-9077"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bz2jm956tp3hd.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010968/v1",
  "fulltext_url": null,
  "id": "bz2jm956tp3hd",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010968/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Supramolecular Self-Assembly in Materials"
    ]
  ],
  "openalex": "W7223404627",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010968/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/bz2jm956tp3hd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.26434/chemrxiv.15010968",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010968/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Supramolecular Self-Assembly in Materials",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Self-assembly of DNA-β-sheet peptide conjugates into emergent micrometer-sized rods",
  "title_text": "Self-assembly of DNA-β-sheet peptide conjugates into emergent micrometer-sized rods",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/bz2jm956tp3hd",
  "venue": "ChemRxiv",
  "versions": []
}