{
  "abstract": "Nickel complexes are able to undergo reactions with organohalides by a variety of fundamental steps, which can be either one-electron or two-electron in nature. Two electron processes are typically some flavour of oxidative addition (OA), but various mechanisms have been proposed for the one-electron reactions, including inner-sphere halogen atom abstraction (HAA) and outer-sphere single electron transfer (SET). It was recently proposed that the steric bulk of a substrate can be used as an indicator of whether HAA is feasible, and therefore that SET was in operation for a specific and bulky substrate. However, the steric requirements for HAA by nickel have not yet been systematically assessed. Here we report a structured assessment of how HAA feasibility might vary with ligand and substrate steric impact. We find that HAA by [Ni(PMe 3 ) 3 ] is feasible even for sterically very hindered substrates. Systems with ferrocene-derived bisphosphine ligands tend to prefer HAA when the ligand and/or the substrate are very sterically bulky.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Risnita Vicky Listyarini"
    },
    {
      "name": "Ryan Oliver"
    },
    {
      "name": "Hio U. Lao"
    },
    {
      "name": "David J. Nelson",
      "orcid": "0000-0002-9461-5182"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bzj1q4qacwcd3.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009547/v1",
  "fulltext_url": null,
  "id": "bzj1q4qacwcd3",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009547/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Catalytic Cross-Coupling Reactions"
    ]
  ],
  "openalex": "W7214674355",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009547/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-28",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/bzj1q4qacwcd3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009547",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009547/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic Cross-Coupling Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Understanding the steric demand of the reactions of nickel(0) complexes with aryl halide substrates",
  "title_text": "Understanding the steric demand of the reactions of nickel(0) complexes with aryl halide substrates",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/bzj1q4qacwcd3",
  "venue": "ChemRxiv",
  "versions": []
}