{
  "abstract": "During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically, producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and fully resets precursor cell lifespan, even for replicatively aged cells. However, the mechanisms responsible for gametogenic rejuvenation have remained mysterious. This is partly due to the existing methods to quantify lifespan resetting in this context, which are limited to low-throughput and labor-intensive approaches. Here, we introduce a high-throughput assay that allows systematic characterization of factors required for gametogenic rejuvenation. With this approach, we show that we can sensitively measure a wide range of gamete replicative lifespans that are consistent with established mutants. Excitingly, we also discover that Atg39 and Atg40, receptors involved in selective autophagy of the ER, are molecular determinants of gametogenic rejuvenation. This technique will enable systematic identification of the molecular factors that drive gametogenic rejuvenation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. silvan.spiri@berkeley.edu.",
    "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.",
    "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. elcin@berkeley.edu.",
    "California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA. elcin@berkeley.edu.",
    "Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. elcin@berkeley.edu.",
    "Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. gabrar@berkeley.edu.",
    "California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA. gabrar@berkeley.edu.",
    "Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. gabrar@berkeley.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Silvan Spiri",
      "orcid": "0000-0002-7124-3056"
    },
    {
      "affs": [
        1
      ],
      "name": "Tina Lynn Sing"
    },
    {
      "affs": [
        1
      ],
      "name": "Nhi Phung",
      "orcid": "0009-0000-5639-852X"
    },
    {
      "affs": [
        1
      ],
      "name": "Jay S Goodman",
      "orcid": "0000-0002-4788-3918"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Elçin Ünal",
      "orcid": "0000-0002-6768-609X"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Gloria Ann Brar",
      "orcid": "0000-0002-8560-9581"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bzp23ft1cezq1.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77993-0",
  "fulltext_url": "https://europepmc.org/articles/PMC13720134",
  "id": "bzp23ft1cezq1",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42957684",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7214793562",
  "pdf_url": "https://europepmc.org/articles/PMC13720134?pdf=render",
  "pmcid": "PMC13720134",
  "pmid": "42957684",
  "published": "2026-09-29",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/bzp23ft1cezq1.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:29Z",
      "native_id": "MED:42957684",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42957684"
    },
    {
      "first_seen": "2026-11-02T12:23:58Z",
      "native_id": "PMC13720134",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-77993-0"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "A role for selective ER autophagy in gametogenic rejuvenation revealed by high-throughput lifespan profiling.",
  "title_text": "A role for selective ER autophagy in gametogenic rejuvenation revealed by high-throughput lifespan profiling.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:04Z",
  "url": "https://research.draconitic.com/paper/bzp23ft1cezq1",
  "venue": "Nature communications",
  "versions": []
}