{
  "abstract": "Heart failure is associated with widespread epigenetic remodeling in cardiomyocytes, but the chromatin regulators driving this process remain poorly defined. We identify the histone H3K4 demethylase KDM5A as a key epigenetic mediator of heart failure in a cardiomyocyte-specific lamin A-deficient mouse model. Disease-associated activation of KDM5A leads to redistribution of promoter histone H3 lysine 4 trimethylation and repression of genes regulating sarcomere structure and mitochondrial oxidative metabolism. Genetic deletion of Kdm5a restores histone H3 lysine 4 trimethylation enrichment, reactivates cardiac and metabolic transcriptional programs, improves cardiac function, and prolongs survival. These findings identify KDM5A-mediated chromatin remodeling as a previously unrecognized mechanism of heart failure and highlight KDM5A as a potential therapeutic target.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Cardiovascular Genetics, Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.",
    "Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.",
    "Center for Cardiovascular Genetics, Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA. Electronic address: Priyatansh.Gurha@uth.tmc.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Manisha Deogharia"
    },
    {
      "affs": [
        0
      ],
      "name": "Chitra Lekha Reddy"
    },
    {
      "affs": [
        0
      ],
      "name": "Ritapa Chaudhuri"
    },
    {
      "affs": [
        0
      ],
      "name": "Manogna Sai Chirasani"
    },
    {
      "affs": [
        1
      ],
      "name": "Abhinav K Jain"
    },
    {
      "affs": [
        0
      ],
      "name": "Leila Rouhi"
    },
    {
      "affs": [
        0
      ],
      "name": "A J Marian"
    },
    {
      "affs": [
        2
      ],
      "name": "Priyatansh Gurha"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/bzv3489k8vwyp.bib",
  "cited_by": 1,
  "doi": "10.1016/j.jacbts.2026.101714",
  "fulltext_url": "https://europepmc.org/articles/PMC13675707",
  "id": "bzv3489k8vwyp",
  "issns": [
    "2452-302X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42849122",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Cardiomyopathy and Myosin Studies"
    ]
  ],
  "openalex": "W7220992827",
  "pdf_url": "https://europepmc.org/articles/PMC13675707?pdf=render",
  "pmcid": "PMC13675707",
  "pmid": "42849122",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/bzv3489k8vwyp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42849122",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42849122"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiomyopathy and Myosin Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Histone Demethylase KDM5A Is Activated and Pathogenic in a Mouse Model of LMNA-Cardiomyopathy.",
  "title_text": "Histone Demethylase KDM5A Is Activated and Pathogenic in a Mouse Model of LMNA-Cardiomyopathy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/bzv3489k8vwyp",
  "venue": "JACC. Basic to translational science",
  "versions": []
}