{
  "abstract": "BACKGROUND: Neurofilament light chain (NfL) indexes neuroaxonal injury and relates to poorer cognition. Higher carotid–femoral pulse wave velocity (cfPWV) arterial stiffness strengthens NfL–cognition associations, but reflects both pressure‐standardized structural stiffness (S–PWV) and transient hemodynamic load‐dependent pulse wave velocity (LD–PWV). We tested which component drives this interaction.\n\nMETHODS: Plasma NfL and cfPWV were measured in 552 cognitively unimpaired older adults. cfPWV was decomposed into S–PWV and LD–PWV. Five latent cognitive domains were modeled. Linear regression tested PWV moderators of NfL–cognition associations.\n\nRESULTS: NfL correlated with all domains (r = −0.116 to −0.185; P < 0.01) and was unrelated to S–PWV or LD–PWV. Total–PWV moderated NfL–working memory (β = −0.268, P = 0.019). NfL × S–PWV interactions were significant for episodic memory, working memory, and processing speed (P < 0.040), but did not meet false discovery rate correction (q ≈ 0.067). NfL × LD–PWV interactions were non‐significant (P > 0.09).\n\nDISCUSSION: Nominal interactions were more consistent for S–PWV. Findings did not provide multiplicity‐adjusted evidence of component‐specific moderation.\n\nClinicalTrials.gov: NCT02875301",
  "abstract_shown": true,
  "affiliations": [
    "AdventHealth Research Institute, Neuroscience Orlando Florida USA",
    "The Hinda and Arthur Marcus Institute for Aging Research Hebrew SeniorLife Boston Massachusetts USA",
    "Centre for Healthy Ageing, Health Futures Institute Murdoch University Perth Western Australia Australia",
    "Department of Psychology University of Pittsburgh Pittsburgh Pennsylvania USA",
    "Wake Forest University School of Medicine Winston‐Salem North Carolina USA",
    "Department of Medicine–Division of Cardiovascular Medicine William S. Middleton Memorial Veteran's Hospital Madison Wisconsin USA",
    "Department of Medicine, Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA",
    "Department of Epidemiology, School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA",
    "Department of Psychiatry Weill Cornell Medicine New York New York USA",
    "Department of Psychiatry, School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA",
    "Alzheimer's Disease Research Center University of Pittsburgh Pittsburgh Pennsylvania USA",
    "Biofluid Biomarker Laboratory Western Psychiatric Hospital, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA",
    "Alzheimer's Disease Research Center University of Kansas Kansas City Kansas USA",
    "Department of Neurology University of Kansas Medical Center Kansas City Kansas USA",
    "Department of Internal Medicine, Division of Physical Activity and Weight Management University of Kansas Medical Center Kansas City Kansas USA",
    "Department of Medicine (Geriatrics and Cardiology) and the Pittsburgh Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System University of Pittsburgh Pittsburgh Pennsylvania USA",
    "Beckman Institute for Advanced Science and Technology University of Illinois at Urbana Champaign Urbana Illinois USA",
    "Department of Health and Kinesiology University of Illinois at Urbana Champaign Urbana Illinois USA",
    "Department of Psychology Northeastern University Boston Massachusetts USA",
    "Institute for Cognitive & Brain Health Northeastern University Boston Massachusetts USA",
    "Department of Physical Therapy, Movement, & Rehabilitation Sciences Northeastern University Boston Massachusetts USA",
    "Department of Biostatistics and Health Data Science, School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Amani M. Norling",
      "orcid": "0000-0003-1638-5913"
    },
    {
      "affs": [
        0
      ],
      "name": "Audrey M. Collins"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Kelsey R. Sewell"
    },
    {
      "affs": [
        0
      ],
      "name": "Lu Wan"
    },
    {
      "affs": [
        3
      ],
      "name": "George Grove"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiqing Huang"
    },
    {
      "affs": [
        4
      ],
      "name": "Timothy M. Hughes"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Adam D. Gepner"
    },
    {
      "affs": [
        7
      ],
      "name": "Akira Sekikawa"
    },
    {
      "affs": [
        0,
        8
      ],
      "name": "Lauren E. Oberlin"
    },
    {
      "affs": [
        9,
        10,
        11
      ],
      "name": "Thomas K. Karikari"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Jill K. Morris"
    },
    {
      "affs": [
        14
      ],
      "name": "John M. Jakicic"
    },
    {
      "affs": [
        14
      ],
      "name": "Renee J. Rogers"
    },
    {
      "affs": [
        15
      ],
      "name": "Daniel E. Forman"
    },
    {
      "affs": [
        16,
        17
      ],
      "name": "Edward McAuley"
    },
    {
      "affs": [
        16
      ],
      "name": "Arthur F. Kramer"
    },
    {
      "affs": [
        18,
        19,
        20
      ],
      "name": "Charles H. Hillman"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Eric D. Vidoni"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Sandra A. Billinger"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Jeffrey M. Burns"
    },
    {
      "affs": [
        3
      ],
      "name": "Anna L. Marsland"
    },
    {
      "affs": [
        9,
        21
      ],
      "name": "Chaeryon Kang"
    },
    {
      "affs": [
        0
      ],
      "name": "Kirk I. Erickson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c0476p11ebb6z.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70507",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13728322/",
  "id": "c0476p11ebb6z",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://doi.org/10.1002/dad2.70507",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2705|Cardiovascular Health and Disease Prevention"
    ]
  ],
  "openalex": "W7225167991",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.70507",
  "pmcid": "PMC13728322",
  "pmid": "42979025",
  "published": "2026-11-02",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/c0476p11ebb6z.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:24:01Z",
      "native_id": "PMC13728322",
      "source": "pmc",
      "url": "https://doi.org/10.1002/dad2.70507"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Health and Disease Prevention",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Decomposed arterial stiffness and NfL–cognition association in older adults: The IGNITE study",
  "title_text": "Decomposed arterial stiffness and NfL–cognition association in older adults: The IGNITE study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:20Z",
  "url": "https://research.draconitic.com/paper/c0476p11ebb6z",
  "venue": "Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring",
  "versions": []
}