{
  "abstract": "Xenograft sorting tools separate sequenced DNA reads by species. We have enhanced the computational method and tool Xengsort to enable efficient epigenetic profiling of patient-derived xenograft models; it now supports cytosine-converted whole genome or reduced-representation data. Benchmarking Xengsort against several established methods (ICRG, bamcmp, XenofilteR) revealed consistently high accuracy across tools, but Xengsort outperformed the other tools in computational efficiency due to its alignment-free design.",
  "abstract_shown": true,
  "affiliations": [
    "Saarland University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "S. Altendorfer"
    },
    {
      "name": "J. Zentgraf"
    },
    {
      "name": "J. E. Schmitz"
    },
    {
      "name": "C. Plass"
    },
    {
      "name": "C. Gerhauser"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Rahmann"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c0559p9p1pn3p.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.06.756952",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756952v1.full",
  "id": "c0559p9p1pn3p",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756952v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "1312|Epigenetics and DNA Methylation"
    ]
  ],
  "openalex": "W7221503959",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756952v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c0559p9p1pn3p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:24Z",
      "native_id": "10.64898/2026.10.06.756952",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.06.756952v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "High-performance xenograft read-sorting for DNA methylation analysis",
  "title_text": "High-performance xenograft read-sorting for DNA methylation analysis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:24Z",
  "url": "https://research.draconitic.com/paper/c0559p9p1pn3p",
  "venue": "bioRxiv",
  "versions": []
}