{
  "abstract": "Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers and enable the integration of multiple data types. Data from islets of the first 299 organ donors without diabetes analyzed using this pipeline highlights substantial heterogeneity in islet cell composition associated with hormone secretory traits, sex, reported race and ethnicity, genetically predicted ancestry, and genetic risk for type 2 diabetes (T2D). While α and β cell composition influenced insulin and glucagon secretory traits, the abundance of δ cells showed the strongest association with insulin secretion and was also associated with the genetic risk score (GRS) for T2D. These findings have important implications for understanding mechanisms underlying diabetes heterogeneity and islet dysfunction and may provide insight into strategies for personalized medicine and β cell replacement therapy. Our investigation highlights substantial heterogeneity in islet cell composition associated with hormone secretory traits, sex, reported race and ethnicity, genetically predicted ancestry, and genetic risk for type 2 diabetes (T2D).",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu",
    "Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu",
    "Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu",
    "Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu",
    "Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. cevansmo@iu.edu",
    "The Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu",
    "The Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu",
    "Indiana University School of Medicine",
    "Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA",
    "Vanderbilt University School of Medicine",
    "Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA",
    "Vanderbilt University Medical Center",
    "Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA",
    "Stanford School of Medicine",
    "Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA",
    "Vanderbilt University",
    "Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA",
    "VA Tennessee Valley Healthcare System, Nashville, TN, USA",
    "National Institutes of Health",
    "Division of Diabetes, Endocrinology, & Metabolic Diseases, National Institutes of Health, Bethesda, MD, USA",
    "Department of Genetics, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu",
    "Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu",
    "Stanford Diabetes Center, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu",
    "City of Hope",
    "Department of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA. jniland@coh.org",
    "Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. marcela.brissova@vanderbilt.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 30,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        5,
        6,
        7
      ],
      "name": "Carmella Evans‐Molina",
      "orcid": "0000-0001-7764-8663"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Yasminye D. Pettway",
      "orcid": "0000-0001-6660-3013"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Diane C. Saunders",
      "orcid": "0000-0002-8849-6746"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Seth A. Sharp",
      "orcid": "0000-0002-0607-9990"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Thomas S. R. Bate",
      "orcid": "0000-0002-1517-9520"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Han Sun",
      "orcid": "0000-0002-3390-0027"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Heather H. Durai"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Shaojun Mei",
      "orcid": "0000-0003-4695-876X"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Anastasia Coldren"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Corey Davis"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Conrad Reihsmann",
      "orcid": "0000-0002-1482-5359"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Alexander L. Hopkirk",
      "orcid": "0000-0002-1194-4221"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Jay Taylor",
      "orcid": "0009-0009-7407-7864"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Amber M. Bradley",
      "orcid": "0000-0002-4912-371X"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Radhika Aramandla",
      "orcid": "0009-0009-6399-9492"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Greg Poffenberger",
      "orcid": "0000-0002-7363-4683"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Adel Eskaros",
      "orcid": "0000-0001-9028-338X"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Regina Jenkins"
    },
    {
      "affs": [
        14,
        11
      ],
      "name": "Danni Shi"
    },
    {
      "affs": [
        14,
        11
      ],
      "name": "Ke Xu",
      "orcid": "0000-0002-6153-5055"
    },
    {
      "affs": [
        14,
        13
      ],
      "name": "Hakmook Kang",
      "orcid": "0000-0001-6876-4021"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Varsha Rajesh"
    },
    {
      "affs": [
        12,
        11
      ],
      "name": "Swaraj Thaman",
      "orcid": "0000-0002-1306-2353"
    },
    {
      "affs": [
        10,
        15
      ],
      "name": "Fan Feng",
      "orcid": "0000-0002-5990-312X"
    },
    {
      "affs": [
        16,
        11
      ],
      "name": "Jean‐Philippe Cartailler",
      "orcid": "0000-0002-0312-2391"
    },
    {
      "affs": [
        8,
        10,
        17,
        18
      ],
      "name": "Alvin C. Powers",
      "orcid": "0000-0003-1941-5786"
    },
    {
      "affs": [
        19,
        13
      ],
      "name": "Kristin M. Abraham"
    },
    {
      "affs": [
        20,
        21,
        22,
        23
      ],
      "name": "Anna L. Gloyn",
      "orcid": "0000-0003-1205-1844"
    },
    {
      "affs": [
        24,
        11
      ],
      "name": "Joyce C. Niland",
      "orcid": "0000-0002-3001-517X"
    },
    {
      "affs": [
        25
      ],
      "name": "Marcela Briššová",
      "orcid": "0000-0002-4999-3280"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c07be3634rbe5.bib",
  "cited_by": 12,
  "doi": "10.1038/s41467-026-70689-5",
  "fulltext_url": null,
  "id": "c07be3634rbe5",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-70689-5",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "2746|Pancreatic function and diabetes"
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  "openalex": "W4404579359",
  "pdf_url": null,
  "pmcid": "PMC11601672",
  "pmid": "39605606",
  "published": "2026-05-12",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/c07be3634rbe5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:56Z",
      "native_id": "W4404579359",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41467-026-70689-5"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Pancreatic function and diabetes",
      "subfield": "surgery"
    }
  ],
  "title": "Heterogeneous endocrine cell composition defines human islet functional phenotypes",
  "title_text": "Heterogeneous endocrine cell composition defines human islet functional phenotypes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T13:21:08Z",
  "url": "https://research.draconitic.com/paper/c07be3634rbe5",
  "venue": "Nature Communications",
  "versions": []
}