{
  "abstract": "Septal GABAergic projection neurons form distinct pathways to subregions of the hippocampal formation, including the hippocampus proper and the medial and lateral entorhinal cortices. Parvalbumin (PV+) and calbindin expressing (CB+) projections target different types of interneurons and thereby differentially regulate neuronal activity in the downstream area. Consistent with the idea of dissociable functional roles, inhibition of septal PV+ neurons impairs reference memory whereas inhibition of septal CB+ neurons impairs both reference and working memory. Here, we show that these functions are differentially supported by specific projection pathways: PV+ projections to the dorsal hippocampus and medial entorhinal cortex (MEC) support reference memory, whereas CB+ projections to the MEC support both reference and working memory. At the network level, septal PV+, but not CB+, neurons regulate theta oscillations. Together, these findings further define the roles of septal PV+ and CB+ pathways in orchestrating network activity and supporting specific forms of memory.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Neurobiology at the Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "D. A. A. MacLaren"
    },
    {
      "name": "K. M. Saidov"
    },
    {
      "name": "M. I. Schlesiger"
    },
    {
      "affs": [
        0
      ],
      "name": "H. Monyer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c0kq9mfx464v0.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.01.763440",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763440v1.full",
  "id": "c0kq9mfx464v0",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763440v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763440v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c0kq9mfx464v0.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:30Z",
      "native_id": "10.64898/2026.11.01.763440",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.01.763440v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Distinct medial septal GABAergic pathways differentially regulate spatial memory and network activity",
  "title_text": "Distinct medial septal GABAergic pathways differentially regulate spatial memory and network activity",
  "type": "preprint",
  "updated_at": "2026-11-05T00:20:52Z",
  "url": "https://research.draconitic.com/paper/c0kq9mfx464v0",
  "venue": "bioRxiv",
  "versions": []
}