{
  "abstract": "This study developed a dietary polysaccharide-stabilized peptide-Fe²⁺ composite beverage to address iron deficiency anemia (IDA). Through single-factor and orthogonal experiments, the formulation was optimized (cranberry/blueberry concentrate ratio 4:6, 600 mL/L; FA-COS@Peptide-Fe²⁺@PTry-CMC 200 mL/L; vitamin C 1.5 g/L; pectin 0.06 g/L), and processing parameters were determined (homogenization: 12,000 rpm, 20 min; sterilization: 95 °C, 15 min). Storage stability was optimal at 4 °C in dark conditions. Under the optimal processing conditions, the beverage attained a maximum suspension stability of 17.74% and the optimized formulation achieved a highest sensory score of 94.0 (out of 100). In vivo experiments showed that the beverage dose-dependently restored hematological parameters (e.g., HGB, SI, TIBC) and tissue iron levels, alleviated intestinal oxidative stress and inflammatory markers in IDA mice, while repairing colonic mucosal damage without adverse effects. The beverage demonstrated high iron-supplementing efficacy and excellent biosafety, offering a promising strategy for IDA intervention.",
  "abstract_shown": true,
  "affiliations": [
    "College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.",
    "Key Laboratory of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China.",
    "State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266400, China.",
    "Institute of Agro-Products Processing Science and Technology, Guangxi Academy of Agricultural Sciences, Nanning 530007, China.",
    "Sanya Tropical Fisheries Research Institute, Sanya 572000, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yongqian Liang"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Shanting Lin"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Shengjun Chen",
      "orcid": "0000-0003-0841-3857"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Yongqiang Zhao",
      "orcid": "0000-0001-8729-9583"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Hui Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhenxing Li"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Xiao Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c164n7gspse3t.bib",
  "cited_by": 0,
  "doi": "10.3390/foods15203644",
  "fulltext_url": "https://europepmc.org/articles/PMC13704524",
  "id": "c164n7gspse3t",
  "issns": [
    "2304-8158"
  ],
  "landing_url": "https://europepmc.org/article/MED/42940281",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2720|Iron Metabolism and Disorders"
    ]
  ],
  "openalex": "W7221827482",
  "pdf_url": "https://europepmc.org/articles/PMC13704524?pdf=render",
  "pmcid": "PMC13704524",
  "pmid": "42940281",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c164n7gspse3t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42940281",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42940281"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Iron Metabolism and Disorders",
      "subfield": "general"
    }
  ],
  "title": "Development and Evaluation of a Dietary Polysaccharide-Stabilized Peptide-Fe²⁺ Complex Beverage for Iron Deficiency Anemia Intervention.",
  "title_text": "Development and Evaluation of a Dietary Polysaccharide-Stabilized Peptide-Fe²⁺ Complex Beverage for Iron Deficiency Anemia Intervention.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/c164n7gspse3t",
  "venue": "Foods (Basel, Switzerland)",
  "versions": []
}