{
  "abstract": "Despite extensive evidence linking inflammation to obesity, a clear mechanistic model for how inflammatory signals regulate adipose tissue development remains lacking. Here, using in vitro and in vivo models, we demonstrate that transient primary cilium assembly and cilium-dependent inflammatory signaling in preadipocytes serve as key initiators of adipogenesis. Adipose stem cells transiently activate a ciliary gene program to form ciliated preadipocytes, which subsequently commit to adipogenesis and lose their cilia upon further differentiation. We further show that C-C motif chemokine receptor 2 (CCR2) localizes to the primary cilia of preadipocytes. High-fat diet feeding remodels the adipose tissue microenvironment, elevating the pro-inflammatory chemokine C-C motif chemokine ligand 2 (CCL2), which engages the cilium-localized CCR2 to initiate adipogenesis via an extracellular signal-regulated kinase (ERK)-dependent signaling pathway. Disruption of cilium assembly or interference with the downstream CCL2/CCR2-ERK signaling axis severely impairs adipogenesis. These findings reveal that the transient assembly of primary cilia in preadipocytes establishes a temporally confined window of heightened sensitivity to environmental inflammatory cues, directing cell fate decisions in adipose tissue development.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China.",
    "Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.",
    "Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China. junzhou@sdnu.edu.cn.",
    "State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. junzhou@sdnu.edu.cn.",
    "State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. yunfanyang@nankai.edu.cn."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yue Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yun Kong"
    },
    {
      "affs": [
        0
      ],
      "name": "Weitao Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanchun Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Shaodong Yan"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Jun Zhou",
      "orcid": "0000-0003-3131-7804"
    },
    {
      "affs": [
        4
      ],
      "name": "Yunfan Yang",
      "orcid": "0000-0002-5266-7208"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c17j6hjvezy9s.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77826-0",
  "fulltext_url": "https://europepmc.org/articles/PMC13677747",
  "id": "c17j6hjvezy9s",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42893979",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Genetic and Kidney Cyst Diseases"
    ]
  ],
  "openalex": "W7213393644",
  "pdf_url": "https://europepmc.org/articles/PMC13677747?pdf=render",
  "pmcid": "PMC13677747",
  "pmid": "42893979",
  "published": "2026-09-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c17j6hjvezy9s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42893979",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42893979"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetic and Kidney Cyst Diseases",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Transient activation of ciliary CCR2 signaling promotes the initiation of adipogenesis.",
  "title_text": "Transient activation of ciliary CCR2 signaling promotes the initiation of adipogenesis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/c17j6hjvezy9s",
  "venue": "Nature communications",
  "versions": []
}