{
  "abstract": "Background The abridged Institut Pasteur du Cambodge 3-session intradermal (ID) rabies post-exposure prophylaxis (PEP) regimen has been shown to be as safe and immunogenic as the 4-session regimen previously recommended by the World Health Organization. This regimen reduces time and cost and improves adherence and access to PEP for underserved people. In our study, we aimed to compare long-term and anamnestic immune response after a rabies vaccine booster dose in people previously vaccinated with a 3- or 4-session ID PEP. Methods In this prospective, multisite, comparative immunogenicity study, we measured rabies virus (RABV)–neutralizing antibody in 181 persons who had previously received 3- or 4-session ID PEP 2, 5, or 10 years earlier in Cambodia or Madagascar at day 0 and day 7 after a booster. In addition, RABV-specific T-cell response was evaluated in a subgroup of 35 Cambodian participants. Results All participants had RABV-neutralizing antibody titers considered adequate (≥0.5 IU/mL) on day 7 after the booster dose. The overall geometric mean titer of rabies antibody on day 0 and day 7 did not differ significantly between the 2 groups. Furthermore, RABV-specific T-cell response was similar regardless of the ID PEP regimen initially received in a subgroup of 35 participants. Conclusions In this multisite, real-world study, we showed that the 3-session ID PEP regimen provides robust long-term immunogenicity for up to 10 years after initial PEP and ensures the induction of an adequate anamnestic response within 7 days after an additional booster in all participants.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 22,
  "authors": [
    {
      "name": "Perrine Parize"
    },
    {
      "name": "Sothy Touch"
    },
    {
      "name": "Vaomalala Raharimanga"
    },
    {
      "name": "Nisa Ya"
    },
    {
      "name": "Katherine Worsley-Tonks",
      "orcid": "0000-0001-7485-0225"
    },
    {
      "name": "Lauriane Kergoat",
      "orcid": "0000-0002-5609-4398"
    },
    {
      "name": "Pisey Thai"
    },
    {
      "name": "Soa Fy Andriamandimby"
    },
    {
      "name": "Saraden In"
    },
    {
      "name": "Anou Dreyfus"
    },
    {
      "name": "Malen Chan"
    },
    {
      "name": "Mino Harimbola Razafindramparany"
    },
    {
      "name": "Veasna Duong",
      "orcid": "0000-0003-0353-1678"
    },
    {
      "name": "Ravo Ramiandrasoa"
    },
    {
      "name": "Yiksing Peng"
    },
    {
      "name": "Tineke Cantaert",
      "orcid": "0000-0002-8911-1502"
    },
    {
      "name": "Philippe Dussart",
      "orcid": "0000-0002-1931-3037"
    },
    {
      "name": "Guilherme Dias de Melo",
      "orcid": "0000-0003-0747-7760"
    },
    {
      "name": "Sowath Ly"
    },
    {
      "name": "Rindra Vatosoa Randremanana",
      "orcid": "0000-0002-6174-8827"
    },
    {
      "name": "Arnaud Tarantola"
    },
    {
      "name": "Hervé Bourhy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c1cy64y5zf5dy.bib",
  "cited_by": 1,
  "doi": "10.1093/cid/ciag368",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715973/",
  "id": "c1cy64y5zf5dy",
  "issns": [
    "1058-4838",
    "1537-6591"
  ],
  "landing_url": "https://pasteur.hal.science/pasteur-05842462v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "heading",
      "AcademicSubjects/MED00290"
    ],
    [
      "heading",
      "Major Article"
    ],
    [
      "heading",
      "Vaccines"
    ],
    [
      "openalex",
      "2406|Rabies epidemiology and control"
    ]
  ],
  "openalex": "W7164866695",
  "pdf_url": "https://pasteur.hal.science/pasteur-05842462/document",
  "pmcid": "PMC13715973",
  "pmid": "42296188",
  "published": "2026-06-15",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/c1cy64y5zf5dy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "pasteur-05842462",
      "source": "hal",
      "url": "https://pasteur.hal.science/pasteur-05842462v1"
    },
    {
      "first_seen": "2026-11-01T12:23:08Z",
      "native_id": "PMC13715973",
      "source": "pmc",
      "url": "https://doi.org/10.1093/cid/ciag368"
    }
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2406|Rabies epidemiology and control",
      "subfield": "microbiology"
    }
  ],
  "title": "Comparative Long-Term Immunogenicity and Boosting of 3-Session Versus 4-Session Intradermal Rabies Post-Exposure Prophylaxis Regimens in Cambodia and Madagascar: The RESIST-3 Study",
  "title_text": "Comparative Long-Term Immunogenicity and Boosting of 3-Session Versus 4-Session Intradermal Rabies Post-Exposure Prophylaxis Regimens in Cambodia and Madagascar: The RESIST-3 Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:08Z",
  "url": "https://research.draconitic.com/paper/c1cy64y5zf5dy",
  "venue": "Clinical Infectious Diseases",
  "versions": []
}