{
  "abstract": "Objective: To investigate the association between the C-reactive protein-to-lymphocyte ratio (CLR) and the risk of complicated appendicitis, and to evaluate its incremental diagnostic value over conventional ultrasound features.\n\nMaterials and methods: In this retrospective cohort study, 230 patients with ultrasound-diagnosed appendicitis between December 2021 and February 2024 were included. Complicated appendicitis was confirmed by postoperative pathology. Associations were assessed using logistic regression. The diagnostic performance of a model with five ultrasound features was compared to a model adding ln CLR using ROC curve analysis and the DeLong test.\n\nResults: Among 230 patients, 34 (14.8%) were identified as having complicated appendicitis. Higher ln CLR showed an independent association with an increased risk, with an adjusted odds ratio of 2.54 (95% CI: 1.47–4.41, p = 0.001). Patients in the lowest CLR tertile appeared to have a higher adjusted odds compared with those in the highest tertile (OR = 5.14, 95% CI: 1.18–22.36, p = 0.029). The ultrasound-only model yielded an area under the curve (AUC) of 0.872 (95% CI: 0.816–0.928). The addition of ln CLR was associated with a modest improvement in diagnostic performance, with the AUC increasing to 0.911 (95% CI: 0.868–0.954, p = 0.047).\n\nConclusion: CLR may be independently associated with complicated appendicitis. The integration of CLR with ultrasound features appears to enhance diagnostic accuracy, suggesting that this combined approach could offer a practical tool for preoperative risk stratification.\n\nGraphical Abstract:\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12876-026-05209-2.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ultrasonography, The First Hospital of Putian City, Nanmen West Road, Chengxiang District, Putian, People’s Republic of China",
    "Department of Medical Equipment Department, The First Hospital of Putian City, Putian, China",
    "Department of Anesthesiology, The First Hospital of Putian City, Nanmen West Road, Chengxiang District, Putian, People’s Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bixia Lin"
    },
    {
      "affs": [
        1
      ],
      "name": "Junfan Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Weide Lin",
      "orcid": "0009-0008-5407-786X"
    },
    {
      "affs": [
        0
      ],
      "name": "Meihua Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c1dcze6r7g830.bib",
  "cited_by": 0,
  "doi": "10.1186/s12876-026-05209-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737788/",
  "id": "c1dcze6r7g830",
  "issns": [
    "1471-230X"
  ],
  "landing_url": "https://doi.org/10.1186/s12876-026-05209-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2711|Appendicitis Diagnosis and Management"
    ]
  ],
  "openalex": "W7201887650",
  "pdf_url": null,
  "pmcid": "PMC13737788",
  "pmid": "42989154",
  "published": "2026-08-08",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/c1dcze6r7g830.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:54Z",
      "native_id": "PMC13737788",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12876-026-05209-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2711|Appendicitis Diagnosis and Management",
      "subfield": "general"
    }
  ],
  "title": "Diagnostic value of C-reactive protein-to-lymphocyte ratio combined with ultrasound features for complicated appendicitis: a retrospective cohort study",
  "title_text": "Diagnostic value of C-reactive protein-to-lymphocyte ratio combined with ultrasound features for complicated appendicitis: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:54Z",
  "url": "https://research.draconitic.com/paper/c1dcze6r7g830",
  "venue": "BMC Gastroenterology",
  "versions": []
}