{
  "abstract": "Background and Objectives: Exchange transfusion (ET) remains a critical intervention for severe neonatal hyperbilirubinaemia, yet laboratory associations with ET receipt require careful interpretation. We examined characteristics associated with ET and post-procedure laboratory changes. Materials and Methods: This retrospective tertiary-centre cohort included 98 neonates evaluated between January 2020 and December 2025 (65 received ET; 33 did not). A four-covariate logistic regression model assessed associations with ET receipt. Discrimination, bootstrap optimism, cross-validated calibration and an exploratory creatinine-containing model were examined. Results: Peak total serum bilirubin (TSB) was higher among ET recipients than non-recipients (33.69 ± 6.31 versus 26.19 ± 3.64 mg/dL; p < 0.001). In the primary model (n = 98), peak TSB was associated with ET receipt (adjusted odds ratio 1.31 per mg/dL, 95% confidence interval 1.16–1.48; p < 0.001). The apparent area under the receiver operating characteristic curve (AUC) was 0.860, decreasing to 0.837 after bootstrap optimism correction. An exploratory six-covariate model (n = 97) yielded an apparent AUC of 0.874 and an optimism-corrected AUC of 0.836. Creatinine showed an adjusted association (odds ratio 1.58 per 0.1 mg/dL, 95% confidence interval 1.07–2.32), but its incremental AUC was uncertain (difference 0.014, 95% confidence interval −0.022 to 0.053). Following ET, bilirubin, platelet count and total calcium decreased. Conclusions: Peak TSB strongly distinguished infants who received ET, but this association partly reflects the bilirubin-based indication for treatment. Creatinine did not demonstrate a reliable incremental discrimination benefit. These findings reinforce guideline-based ET assessment and post-exchange monitoring, not the adoption of new treatment thresholds or prediction tools.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Paediatrics, Şanlıurfa Education and Research Hospital, 63200 Şanlıurfa, Türkiye",
    "Department of Paediatrics, Private Hospital, Osmangazi Cad. No:34 Sarigazi, Sancaktepe, 34885 İstanbul, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Aslıhan İzol",
      "orcid": "0000-0002-9957-1828"
    },
    {
      "affs": [
        1
      ],
      "name": "Selçuk Yazıcı",
      "orcid": "0000-0002-6526-9460"
    },
    {
      "affs": [
        0
      ],
      "name": "Sümeyya Ercan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c1h3vbd5hqxjn.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218762",
  "fulltext_url": null,
  "id": "c1h3vbd5hqxjn",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8762",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/c1h3vbd5hqxjn.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:41Z",
      "native_id": "10.3390/jcm15218762",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8762"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Clinical and Laboratory Factors Associated with Exchange Transfusion in Neonates with Severe Hyperbilirubinaemia: A Retrospective Cohort Study",
  "title_text": "Clinical and Laboratory Factors Associated with Exchange Transfusion in Neonates with Severe Hyperbilirubinaemia: A Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/c1h3vbd5hqxjn",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}