{
  "abstract": "AIMS: Despite intensive lipid-lowering therapy, residual cardiovascular risk remains prevalent among patients with coronary artery disease. Although triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) metabolism are closely interrelated, their combined prognostic significance in secondary prevention remains unclear. METHODS: This study analyzed the Clinical Deep Data Accumulation System- Percutaneous Coronary Intervention (CLIDAS-PCI) database, a multicenter Japanese registry of patients with acute coronary syndrome undergoing PCI. Patients were stratified into four combined TG-HDL phenotypic groups using guideline-consistent cutoff values for high TG (≥ 175 mg/dL) and low HDL-C (≤ 40 mg/dL) levels. The primary outcome was a composite of major adverse cardiac and cerebrovascular events plus hospitalization for heart failure and its components. RESULTS: Among 3,352 patients, high TG levels were not associated with the composite outcome but were consistently associated with an increased risk of recurrent myocardial infarction. Although low HDL-C levels were associated with increased cardiovascular risk, this association was attenuated after adjustment for renal function and nutritional status. Combined TG-HDL phenotyping revealed distinct risk profiles: patients with high TG and low HDL-C levels had the highest risk of recurrent myocardial infarction, while those with low TG and low HDL-C levels exhibited a markedly higher risk of cardiovascular death. CONCLUSIONS: In a Japanese secondary prevention cohort undergoing PCI, TG and HDLC demonstrated complementary and outcome-specific prognostic associations. Thus, combined TG-HDL phenotyping using guideline-based cutoffs may provide a simple and clinically relevant approach to stratifying residual cardiovascular risk beyond low-density lipoprotein cholesterol lowering.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 29,
  "authors": [
    {
      "name": "Mitsukuni Kimura"
    },
    {
      "name": "Shunsuke Katsuki"
    },
    {
      "name": "Yasuhiro Nakano"
    },
    {
      "name": "Rissei Hino"
    },
    {
      "name": "Takuya Tabuchi"
    },
    {
      "name": "Genryu Mizokami"
    },
    {
      "name": "Keiji Oi"
    },
    {
      "name": "Mitsuhiro Fukata"
    },
    {
      "name": "Takanori Yamashita"
    },
    {
      "name": "Naoki Nakashima"
    },
    {
      "name": "Takahide Kohro"
    },
    {
      "name": "Tomoyuki Kabutoya"
    },
    {
      "name": "Kazuomi Kario"
    },
    {
      "name": "Yasushi Imai"
    },
    {
      "name": "Hideo Fujita"
    },
    {
      "name": "Naoyuki Akashi"
    },
    {
      "name": "Arihiro Kiyosue"
    },
    {
      "name": "Yoshiko Mizuno"
    },
    {
      "name": "Satoshi Kodera"
    },
    {
      "name": "Masaharu Nakayama"
    },
    {
      "name": "Kotaro Nochioka"
    },
    {
      "name": "Yoshihiro Miyamoto"
    },
    {
      "name": "Kenichi Tsujita"
    },
    {
      "name": "Masanobu Ishii"
    },
    {
      "name": "Hisahiko Sato"
    },
    {
      "name": "Kohtaro Abe"
    },
    {
      "name": "Tetsuya Matoba"
    },
    {
      "name": "Ryozo Nagai"
    },
    {
      "name": "on behalf of the CLIDAS research group"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c1hpzejzn7dxm.bib",
  "cited_by": 0,
  "doi": "10.5551/jat.66189",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66189/_article",
  "id": "c1hpzejzn7dxm",
  "issns": [
    "1880-3873",
    "1340-3478"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66189/_article",
  "language": null,
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7204140169",
  "pdf_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66189/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c1hpzejzn7dxm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.5551/jat.66189",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66189/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "Combined Triglyceride–High-density Lipoprotein Cholesterol Phenotypes and Cardiovascular Outcomes in Japanese Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Insights from Clinical Deep Data Accumulation System-PCI",
  "title_text": "Combined Triglyceride–High-density Lipoprotein Cholesterol Phenotypes and Cardiovascular Outcomes in Japanese Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Insights from Clinical Deep Data Accumulation System-PCI",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/c1hpzejzn7dxm",
  "venue": "Journal of Atherosclerosis and Thrombosis",
  "versions": []
}