{
  "abstract": "Background and purpose\n\nAdmission hyperglycemia is associated with poor outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke, but whether post-EVT glycemic pattern determines functional outcome remains unknown.Methods\n\nA Retrospective Study for the Prediction of Clinical Outcomes in Acute Ischemic Stroke Patients with Thrombectomy study was a hybrid prospective-retrospective multicenter cohort study nested within the Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz trial (NCT05041010) across 24 tertiary stroke centers in South Korea. Patients with ≥80% measurements within 80-140 mg/dL and no value ≥200 mg/dL were classified as normoglycemic (Group 1); the remainder were classified by group-based trajectory modeling into persistently elevated (Group 2) and variable hyperglycemia (Group 3). The primary outcome was 3-month modified Rankin Scale (mRS) distribution.Results\n\nAmong 457 patients, 319 were included (mean age 73.6±12.2 years; 53.6% male): 97 (30.4%) in Group 1, 159 (49.8%) in Group 2, and 63 (19.7%) in Group 3. Groups 2 and 3 had more diabetes and higher hemoglobin A1c; stroke severity, Alberta Stroke Program Early Computed Tomography Scores, and reperfusion status were comparable. Both hyperglycemic groups had lower odds of a favorable mRS shift than Group 1 (adjusted common odds ratio [OR] 0.35, 95% confidence interval [CI] 0.20-0.61 and 0.49, 0.25-0.94). Functional independence (mRS 0-2) was achieved in 63.9% of Group 1 versus 36.5% and 38.1% in Groups 2 and 3 (adjusted OR 0.26, 95% CI 0.13-0.53 and 0.31, 0.13-0.73). No significant difference was observed between Groups 2 and 3.Conclusions\n\nFive-day post-EVT hyperglycemic status was independently associated with worse 3-month functional outcomes beyond chronic glycemic burden, supporting re-evaluation of targeted glycemic interventions during this vulnerable window.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.",
    "Bonghwa-Gun Public Health Center, Bonghwa, Korea.",
    "Clinical Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.",
    "Department of Neurology, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.",
    "Department of Neurology, Chosun University Hospital, Chosun University College of Medicine, Gwangju, Korea.",
    "Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.",
    "Department of Neurology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.",
    "Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.",
    "Department of Neurology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.",
    "Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.",
    "Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea.",
    "Department of Neurology, Dong-A University Hospital, College of Medicine, Dong-A University, Busan, Korea.",
    "Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.",
    "Department of Neurology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.",
    "Department of Neurology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Korea.",
    "Department of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.",
    "Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.",
    "Department of Neurology, Korea University Anam Hospital, Korea University Medicine, Seoul, Korea.",
    "Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.",
    "Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.",
    "Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.",
    "Department of Neurology, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea.",
    "Department of Neurology, Wonkwang University Hospital, School of Medicine, Wonkwang University, Iksan, Korea.",
    "Department of Neurology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Korea.",
    "Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.",
    "Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.",
    "Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.",
    "Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sunkwon7@gmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 34,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kwanju Song"
    },
    {
      "affs": [
        2
      ],
      "name": "Ji Sung Lee"
    },
    {
      "affs": [
        3
      ],
      "name": "Hyun Goo Kang"
    },
    {
      "affs": [
        4
      ],
      "name": "Seong Hwan Ahn"
    },
    {
      "affs": [
        5
      ],
      "name": "Tae-Jin Song"
    },
    {
      "affs": [
        6
      ],
      "name": "Dong-Ick Shin"
    },
    {
      "affs": [
        7
      ],
      "name": "Hee-Joon Bae"
    },
    {
      "affs": [
        8
      ],
      "name": "Chang Hun Kim"
    },
    {
      "affs": [
        9
      ],
      "name": "Sung Hyuk Heo"
    },
    {
      "affs": [
        10
      ],
      "name": "Jin Soo Lee"
    },
    {
      "affs": [
        11
      ],
      "name": "Jae-Kwan Cha"
    },
    {
      "affs": [
        12
      ],
      "name": "Yeong Bae Lee"
    },
    {
      "affs": [
        13
      ],
      "name": "Eung Gyu Kim"
    },
    {
      "affs": [
        14
      ],
      "name": "Man Seok Park"
    },
    {
      "affs": [
        15
      ],
      "name": "Hee-Kwon Park"
    },
    {
      "affs": [
        16
      ],
      "name": "Jinkwon Kim"
    },
    {
      "affs": [
        17
      ],
      "name": "Sungwook Yu"
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    {
      "affs": [
        18
      ],
      "name": "Heejung Mo"
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    {
      "affs": [
        19
      ],
      "name": "Sung Il Sohn"
    },
    {
      "affs": [
        20
      ],
      "name": "Jee Hyun Kwon"
    },
    {
      "affs": [
        21
      ],
      "name": "Jae Guk Kim"
    },
    {
      "affs": [
        22
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      "name": "Young Seo Kim"
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    {
      "affs": [
        23
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      "name": "Jay Chol Choi"
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    {
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        24
      ],
      "name": "Yang-Ha Hwang"
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    {
      "affs": [
        25
      ],
      "name": "Keun Hwa Jung"
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    {
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        8
      ],
      "name": "Soo-Kyoung Kim"
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    {
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        26
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      "name": "Woo Keun Seo"
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    {
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        11
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      "name": "Jung Hwa Seo"
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    {
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        16
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      "name": "Joonsang Yoo"
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    {
      "affs": [
        0
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      "name": "Jun Young Chang"
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    {
      "affs": [
        5
      ],
      "name": "Mooseok Park"
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    {
      "affs": [
        0
      ],
      "name": "Wookjin Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Bum Joon Kim"
    },
    {
      "affs": [
        27
      ],
      "name": "Sun U Kwon"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c1kgc43wg9sk4.bib",
  "cited_by": 0,
  "doi": "10.5853/jos.2026.03867",
  "fulltext_url": "https://europepmc.org/articles/PMC13678338",
  "id": "c1kgc43wg9sk4",
  "issns": [
    "2287-6391",
    "2287-6405"
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  "landing_url": "https://europepmc.org/article/MED/42894455",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "openalex",
      "2713|Acute Ischemic Stroke Management"
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  "openalex": "W7220651111",
  "pdf_url": "https://europepmc.org/articles/PMC13678338?pdf=render",
  "pmcid": "PMC13678338",
  "pmid": "42894455",
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c1kgc43wg9sk4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42894455",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42894455"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Five-Day Glycemic Patterns and 3-Month Functional Outcomes After Endovascular Thrombectomy.",
  "title_text": "Five-Day Glycemic Patterns and 3-Month Functional Outcomes After Endovascular Thrombectomy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/c1kgc43wg9sk4",
  "venue": "Journal of stroke",
  "versions": []
}