{
  "abstract": "Introduction: Calcium oxalate (CaOx) nephrolithiasis is a major global health burden with limited non-pharmacological preventive options. Although moderate beer consumption has been linked to a lower risk of stone formation, the underlying mechanisms remain unclear. This study aimed to investigate the anti-lithogenic effects of dietary beer and the molecular pathways involved.\n\nMethods: We combined a retrospective clinical analysis of 415 urolithiasis patients with a glyoxylic acid–induced mouse model. Male C57BL/6J mice received low-/high-dose beer (3/6 mL/kg) by gavage. We assessed renal histology, urinary biochemistry, oxidative stress, inflammatory responses, and the expression of crystal-adhesion molecules (CD44, OPN, Kim-1).\n\nResults: In the clinical cohort, calcium oxalate monohydrate (COM) stones predominated (79.0%), with a male predominance (2.1:1). In mice, beer intervention lowered urinary oxalate and calcium concentrations, reduced histopathological injury and collagen deposition, downregulated CD44/OPN protein, decreased CD44/Kim-1/TNF-α/IL-1β mRNA expression, and partially preserved catalase and superoxide dismutase activities. The benefits were unlikely attributable to ethanol-induced diuresis, given the minimal gavage volume (~1.2–4% of fluid intake) and low ethanol delivery (~1.4–2.8 mg), which was further supported by unchanged daily water consumption.\n\nDiscussion: These findings demonstrate that dietary beer attenuates CaOx stone formation and modulates urinary, inflammatory, oxidative, and adhesion markers. The anti-lithogenic potential of beer constituents supports the development of purine-free, non-alcoholic, hops-derived polyphenol preparations as a testable hypothesis. However, the absence of appropriate controls precludes attributing the effects to any single component, and these results should not be interpreted as a clinical recommendation to consume beer.",
  "abstract_shown": true,
  "affiliations": [
    "School of Food Science and Engineering, Ningbo University , ,",
    "Department of Clinical Laboratory, Xiangshan Red Cross Taiwan Compatriot Hospital Medical and Health Group , , ,",
    "Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University , ,",
    "School of Laboratory Medicine and Life Science, Wenzhou Medical University , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yaoyao Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Deng"
    },
    {
      "affs": [
        1
      ],
      "name": "Junge Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yanping Dai"
    },
    {
      "affs": [
        3
      ],
      "name": "Xueqian Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Wei Liang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c2343f0adm4cv.bib",
  "cited_by": 0,
  "doi": "10.3389/fnut.2026.1963460",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724572/?tool=EBI",
  "id": "c2343f0adm4cv",
  "issns": [
    "2296-861X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13724572",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2740|Kidney Stones and Urolithiasis Treatments"
    ]
  ],
  "openalex": "W7222968092",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724572/pdf/?tool=EBI",
  "pmcid": "PMC13724572",
  "pmid": "42973793",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/c2343f0adm4cv.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13724572",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13724572"
    },
    {
      "first_seen": "2026-11-04T12:23:07Z",
      "native_id": "PMC13724572",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fnut.2026.1963460"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42973793",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973793"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Kidney Stones and Urolithiasis Treatments",
      "subfield": "general"
    }
  ],
  "title": "Dietary beer ameliorates glyoxylic acid-induced calcium oxalate nephrolithiasis in mice",
  "title_text": "Dietary beer ameliorates glyoxylic acid-induced calcium oxalate nephrolithiasis in mice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:21:18Z",
  "url": "https://research.draconitic.com/paper/c2343f0adm4cv",
  "venue": "Frontiers in nutrition",
  "versions": []
}