{
  "abstract": "Follicular thyroid carcinoma (FTC) is known to occasionally show distant recurrence (DR); however, no prognostic scoring system has been established. Furthermore, although prognostic factors have been identified, their weights as predictors of poor prognosis remain unclear. In this study, we aimed to establish a weighted scoring system for predicting DR in FTC using conventional prognostic factors and Ki-67 labeling index (LI). We analyzed data of 597 patients with FTC without distant metastasis at initial surgery. Tumor size >4 cm, male sex, age ≥60 years, Ki-67 LI >5%, and vascular invasion (VI) ≥4 (V2) significantly and VI 0-4 (V1) marginally affected DR. Wide capsular invasion was not significantly associated with DR. Stepwise model selection using the Akaike Information Criterion identified age ≥60 years, Ki-67 LI >5%, V1, V2, and tumor size >4 cm as suitable components of the score. According to the beta coefficient value, we assigned a score of 2 to age ≥60 years, Ki-67 LI >5%, and V2, and a score of 1 to tumor size >4 cm and V1, with the sum representing the final score. We categorized patients into three categories according to the DR rates: low-risk (score 0-2; n = 388, 65.0%), intermediate-risk (score 3-4; n = 156, 26.1%), and high-risk (score 5-7; n = 53, 8.9%). The 10-year DR-free survival rates declined from the low- to the high-risk categories (96.0% vs. 90.3% vs. 54.9%). These findings indicate that high-risk patients identified using this prognostic scoring model should be carefully monitored for DR following completion thyroidectomy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Yasuhiro Ito"
    },
    {
      "name": "Masashi Yamamoto"
    },
    {
      "name": "Mitsuyoshi Hirokawa"
    },
    {
      "name": "Hiroo Masuoka"
    },
    {
      "name": "Minoru Kihara"
    },
    {
      "name": "Akihiro Miya"
    },
    {
      "name": "Akira Miyauchi"
    },
    {
      "name": "Takashi Akamizu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c3092n2237hx8.bib",
  "cited_by": 0,
  "doi": "10.1507/endocrj.ej26-0184",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/endocrj/73/10/73_EJ26-0184/_article",
  "id": "c3092n2237hx8",
  "issns": [
    "1348-4540",
    "0918-8959"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/endocrj/73/10/73_EJ26-0184/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/endocrinology-metabolism"
    ],
    [
      "openalex",
      "2712|Thyroid Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7164525851",
  "pdf_url": "https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ26-0184/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c3092n2237hx8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "10.1507/endocrj.ej26-0184",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/endocrj/73/10/73_EJ26-0184/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Thyroid Cancer Diagnosis and Treatment",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Establishment of a prognostic score for distant recurrence in follicular thyroid carcinoma",
  "title_text": "Establishment of a prognostic score for distant recurrence in follicular thyroid carcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:20Z",
  "url": "https://research.draconitic.com/paper/c3092n2237hx8",
  "venue": "Endocrine Journal",
  "versions": []
}